Search results

• Identification of genetic prognostic profiles in melanoma

  Evaluation of germline genetic factors implicated in the modulation of melanoma outcome. Evaluation of tumor mutational signatures obtained from ne...

  Research – Research lines

• Evaluation of immune response in melanoma

  Identification of polymorphisms in genes implicated in immunotolerance and immune-response that influence melanoma prognosis. Evaluation of blood i...

  Research – Research lines

• Analysis of the influence of the microbiota in skin cancer

   Evaluation of the role of the gut microbiome in the modulation of immunotherapy response and melanoma outcome.

  Research – Research lines

• Identification of biomarkers for melanoma

  Study of circulating free DNA (cfDNA) as a biomarker for melanoma surveillance. Study of circulating melanoma cells (CMC) and single cell sequencing.

  Research – Research lines

• Development of new treatment strategies for melanoma and other skin tumors

  Research in the dermatological implications of targeted therapies in melanoma. Immunotherapy in melanoma and non-melanoma skin cancer. Development...

  Research – Research lines

• Study of the mechanisms involved in carcinogenesis and photocarcinogenesis in melanoma and non-melanoma skin cancer

  Analysis of topical and oral photoprotection. Study of UV effect in skin and melanocytic nevi using imaging techniques and high-throughput molecula...

  Research – Research lines

• Functional validation of paternally-derived embryo proteins during early embryogenesis

  The goal of this line emerges from the recent results derived from the integrative analysis of the proteome and transcriptome from human sperm, ooc...

  Research – Research lines

• Characterization of exosomes isolated from seminal fluid and development of clinically relevant diagnostic and prognostic biomarkers

  Exosomes contained in the seminal fluid may contribute proteins and RNAs to the sperm. Our first goal is to characterize the protein and RNA conten...

  Research – Research lines

• Characterization of epigenetic signatures in the sperm chromatin

  We have identified a non-random distribution of proteins and genes along the sperm chromatin domains which may represent epigenetic marks involved...

  Research – Research lines

• Molecular alterations in semen from couples with idiopathic infertility

  Molecular alterations at the transcriptiomic and proteomic level are analyzed in sperm and seminal plasma from couples with idiopathic infertility...

  Research – Research lines

• Genetics of endocrine disorders

  We are  studying the genetic aspects of hereditary endocrine disorders (multiple endocrine neoplasia, congenital adrenal hyperplasia and monogenic...

  Research – Research lines

• Characterization of genes involved in the familial non-syndromic differentiated thyroid carcinoma

  Differentiated familial thyroid carcinoma represents 3-9% of thyroid carcinomas. Today, the genes involved in some rare syndromic forms in which th...

  Research – Research lines

• Mechanisms involved in redifferentiation of cancer cells

  Oncogenesis is essentially a cell dedifferentiation process. Molecules that induce  cell differentiation, such as retinoic acid, have been used for...

  Research – Research lines

• Alcoholism and other addictions, and related comorbidities: new diagnosis tools and treatment

  Examples: 1) Identification of the pattern of cannabis, tobacco, and alcohol use as a function of gender and psychiatric comorbidities that predic...

  Research – Research lines

• Therapeutic use of uric acid as peroxynitrite scavenger in acute ischemic stroke

  Studies at our lab have identified the value of uric acid administration after a brain embolism and how it acts in synergy with reperfusion therapi...

  Research – Research lines

• The chemical optimization of cerebral embolectomy

  Mechanical thrombectomy (MT) increases brain reperfusion and the likelihood of good outcome in patients with acute stroke but only about one third...

  Research – Research lines

• Blood-brain barrier disruption in cerebrovascular diseases

  Blood-brain barrier (BBB) disruption is one of the major deleterious mechanisms implicated in the physiopathology of Central Nervous System disease...

  Research – Research lines

• Brain-gut cross-talk in stroke: targeting gut barrier dysfunction and immune responses to improve stroke outcome

  Infection is a frequent complication of stroke associated with mortality and poor neurological recovery. Recent experimental studies show that post...

  Research – Research lines

• Vascular changes with aging and in animal models of vascular dementia

  Vascular dementia (VaD) is recognized as one of the leading causes of cognitive impairment and dementia in the elderly, and has become one of the m...

  Research – Research lines

• Inflammatory and immune responses to stroke

  Brain cell death after acute stroke triggers inflammation, involving glial and endothelial cell activation, invasion of leukocytes to the damaged t...

  Research – Research lines