Search results

• 1. CAR-T and CAR-NK therapy for the treatment of hematological malignancies

  Directed by Álvaro Urbano Preclinical development of CARs for the treatment of malignant diseases. Specifically, we have developed a CAR against B...

  Research – Research lines

• The dynamics of evidence integration during decision making

  Directed by Jaime de la Rocha We study how information, acquired from sensation or from previous experiences, is transformed into decision variabl...

  Research – Research lines

• The neural circuitry of Working Memory (WM): memory interference and disease-mediated deficits

  Directed by Jaime de la Rocha We study how the brain maintains and uses information over short periods (working memory) using behavioral tasks in...

  Research – Research lines

• Midbrain circuitry mediating instrumental learning

  Directed by Hernando Martinez Vergara The Basal Ganglia (BG) are critical for learning, allowing vertebrates to adapt their behavior to maximize u...

  Research – Research lines

• 2. CAR-T cell therapies for solid tumours

  Directed by Álvaro Urbano We are developing novel CAR-T cell therapies for the treatment of solid tumours, with a primary focus on breast and ovar...

  Research – Research lines

• 3. Mechanisms of antitumor cytotoxicity of immune cells (NK and T lymphocytes)

  Directed by Álvaro Urbano We use both NK cells and CAR-NK cells to increase the activity of CART cells avoiding CART cell exhaustion and increasin...

  Research – Research lines

• 4. Allogeneic stem cell transplantation: graft versus host disease (GVHD) and Infectious complications

  Directed by Álvaro Urbano GVHD and Infectious complications are the main problems occurring after allogeneic stem cell transplantation, being resp...

  Research – Research lines

• Study of the molecular mechanisms involved in the development of bleeding and thrombotic disorders

  Our group’s scientific trajectory is focused on the study of the mechanisms involved in the development of haemorrhagic pathologies, particularly t...

  Research – Research lines

• Characterization of endothelial dysfunction in association with different pathological situations

  Some diseases have a high cardiovascular risk, such as chronic kidney failure, diabetes, and obesity, among others, in which we surmise that endoth...

  Research – Research lines

• Search for biomarkers of graft-versus-host disease (GvHD)

  We have identified certain endothelial damage in the context of transplanted haematopoietic progenitor cells in patients. The behaviour of these ma...

  Research – Research lines

• Diagnosis and treatment of thrombotic microangiopathies

  Thrombotic microangiopathies (TMAs) have matching symptoms but may be due to quite different causes. Differential diagnosis of thrombotic thrombocy...

  Research – Research lines

• Evaluation of the physiological and pathological implications of circulating and/or platelet associated procoagulant microparticles in atherothrombosis

  Platelet-derived microparticles facilitate interaction with other cell groups and may have a prothrombotic effect in certain pathological situation...

  Research – Research lines

• Clinical cohorts of prodromal & established disease

  We have built unique prospective cohorts for the clinical and biological characterization of at-risk and prodromal Parkinson’s disease cohorts, e.g...

  Research – Research lines

• Novel diagnostic & prognostic biomarkers

  We seek, set-up and introduce clinically meaningful biomarkers. Hence, we pioneered the alpha-synuclein seed amplification assay in CSF, being the...

  Research – Research lines

• Innovative tissue & cellular models of disease

  We investigate the pathophysiological mechanisms and pathways to unravel novel therapeutic targets of neurodegenerative movement disorders using hu...

  Research – Research lines

• 1. Deep phenotyping of pulmonary hypertension in chronic respiratory diseases

  Our group is currently investigating the endogenous phenotype that determines the heterogeneity of pulmonary hypertension in chronic airway obstruc...

  Research – Research lines

• 2. Metabolic profiling of pulmonary vascular cells in chronic thromboembolic pulmonary hypertension

  To characterize the cell proliferative process that underlies the development of pulmonary hypertension in patients with thromboembolic pulmonary d...

  Research – Research lines

• 3. Assessing prehabilitation as preventive intervention to reduce postoperative complications

  The group is currently involved in a randomized control trial evaluating the impact of a prehabilitation program in the setting of cardiac surgery....

  Research – Research lines

• 4. Evaluating modalities of perioperative ventilatory support

  We are working on several physiological proof-of-concept studies and have promoted three international, multicentre, randomized controlled trials.

  Research – Research lines

• 5. Implementation of integrated care services with a digital health and systems medicine approach

  We are currently undertaking research projects addressed to clinical risk assessment and service selection, promotion of healthy lifestyles, collab...

  Research – Research lines