Search results

• Characterization of endothelial dysfunction in association with different pathological situations

  Some diseases have a high cardiovascular risk, such as chronic kidney failure, diabetes, and obesity, among others, in which we surmise that endoth...

  Research – Research lines

• Search for biomarkers of graft-versus-host disease (GvHD)

  We have identified certain endothelial damage in the context of transplanted haematopoietic progenitor cells in patients. The behaviour of these ma...

  Research – Research lines

• Diagnosis and treatment of thrombotic microangiopathies

  Thrombotic microangiopathies (TMAs) have matching symptoms but may be due to quite different causes. Differential diagnosis of thrombotic thrombocy...

  Research – Research lines

• Evaluation of the physiological and pathological implications of circulating and/or platelet associated procoagulant microparticles in atherothrombosis

  Platelet-derived microparticles facilitate interaction with other cell groups and may have a prothrombotic effect in certain pathological situation...

  Research – Research lines

• Clinical cohorts of prodromal & established disease

  We have built unique prospective cohorts for the clinical and biological characterization of at-risk and prodromal Parkinson’s disease cohorts, e.g...

  Research – Research lines

• Novel diagnostic & prognostic biomarkers

  We seek, set-up and introduce clinically meaningful biomarkers. Hence, we pioneered the alpha-synuclein seed amplification assay in CSF, being the...

  Research – Research lines

• Innovative tissue & cellular models of disease

  We investigate the pathophysiological mechanisms and pathways to unravel novel therapeutic targets of neurodegenerative movement disorders using hu...

  Research – Research lines

• 1. Deep phenotyping of pulmonary hypertension in chronic respiratory diseases

  Our group is currently investigating the endogenous phenotype that determines the heterogeneity of pulmonary hypertension in chronic airway obstruc...

  Research – Research lines

• 2. Metabolic profiling of pulmonary vascular cells in chronic thromboembolic pulmonary hypertension

  To characterize the cell proliferative process that underlies the development of pulmonary hypertension in patients with thromboembolic pulmonary d...

  Research – Research lines

• 3. Assessing prehabilitation as preventive intervention to reduce postoperative complications

  The group is currently involved in a randomized control trial evaluating the impact of a prehabilitation program in the setting of cardiac surgery....

  Research – Research lines

• 4. Evaluating modalities of perioperative ventilatory support

  We are working on several physiological proof-of-concept studies and have promoted three international, multicentre, randomized controlled trials.

  Research – Research lines

• 5. Implementation of integrated care services with a digital health and systems medicine approach

  We are currently undertaking research projects addressed to clinical risk assessment and service selection, promotion of healthy lifestyles, collab...

  Research – Research lines

• 1. Inflammation of the upper and lower respiratory mucosa

  Mechanisms involved in sinonasal and bronchial development, inflammation, and remodeling.

  Research – Research lines

• 2. Sense of smell in health and disease

  Mechanisms involved in olfactory dysfunction (rhinitis, rhinosinusitis, septal perforation) and neurogenesis of sinonasal diseases, traumatic brain...

  Research – Research lines

• 3. Food and drug allergy

  Genetic, immunological, and biochemical mechanisms of respiratory, food, and drug allergy.

  Research – Research lines

• 4. Glucocorticoid resistance

  Mechanisms and biomarkers involved in glucocorticoid resistance of respiratory and non-respiratory diseases.

  Research – Research lines

• 5. Aspirin and Non-Steroidal Anti-inflammatory Drug (NSAID) intolerance

  Mechanisms of allergy and co-factors, regulation of cyclooxygenase, leukotriene, and prostaglandins (PGE2) and their receptors.

  Research – Research lines

• 6. Pathophysiology of eosinophils, mast cells, and basophils

  Anaphylactic reactions (mastocytosis, adapter molecules in the signaling of IgE). Antiinflammatory drug effect in eosinophils and epithelial cells...

  Research – Research lines

• 7. Skull base tumours

  Impact of skull base tumours in quality of life and olfaction. Different surgical approaches.

  Research – Research lines

• 1. Cortical network dynamics

  Neuronal and connectivity properties determining the emergent activity generated by neuronal networks. Aspects of spontaneous rhythmic neural activ...

  Research – Research lines