Replication Stress and Autophagy in Chromosome Instability
Led by C. Mauvezin. Genomic instability is a hallmark of tumor cells, resulting from errors in mitotic progression such as prolonged mitosis, DNA...
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Translational research in liver cancer
Our scientific contributions to advancing knowledge in liver cancer during the last 15 years are summarized as follows: we contributed to the class...
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Molecular and immune classification of HCC
The group contributed to the molecular classification of HCC (Hoshida, NEJM 2008, Chiang Cancer Research 2008) and to the generation of gene signat...
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Identification of determinants of response to immunotherapy in HCC
We developed an 11-gene signature able to predict response to immune checkpoint inhibitors in HCC (Haber Gastroenterology 2022). We also contribute...
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Molecular characterization of human NASH-HCC
We have molecularly characterized human NASH-HCC at the genomic and molecular levels (Pinyol Journal of Hepatology 2021).
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Identification of drivers of oncogenesis as targets for therapies in HCC
Several studies led to the identification of Akt/mTOR pathway [Villanueva Gastroenterology, 2008), EGFR pathway (Keng, Nature Biotech 2009), IGF pa...
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Establishment of a molecular diagnosis and classification of HCC
Gene-set (three genes) based diagnosis of HCC reported in Llovet, Gastroenterology 2006, and included in EASL-EORTC guidelines. In addition, we pro...
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Molecular characterization and identification of drivers of oncogenesis in cholangiocarcinoma
We have contributed to the molecular classification of iCCA (Sia, Gastroenterology 2013) and eCCA (Montal, Journal of Hepatology 2020). We identi...
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Establishment of sorafenib, regorafenib and ramucirumab as standard of care in patients with advanced HCC
The international RCT showing survival benefits for sorafenib vs placebo, presented at plenary session in ASCO (Llovet, New Engl J Med 2008) was a...
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Cannabis and risky use
We explore patterns of consumption, health risks and health-literacy, and the development of standardized measures to assess exposure, literacy, an...
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Addictions, lifestyles, and public health
We address population-level determinants, prevention strategies with an integrated approach (i.e. alongside physical activity, diet or other risk f...
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Digital health and addictions
Digital health constitutes a cross‑cutting research axis through which we leverage digital tools to enhance prevention, early identification, acces...
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Genomic alterations in aggressive large B-cell lymphoma
Directed by Silvia Beà To comprehensively characterize the genetic and molecular profiles of aggressive B-cell lymphomas in order to identify accu...
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Head Neck Tumors
Directed by Dr. Isabel Vilaseca, Dr. F. Xavier Avilés and Dr. Neus Basté Multiomic characterisation of head and neck cancer and its impact in a...
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CAF Plasticity and Heterogeneity in desmoplastic tumors
We are interested in deciphering and dissecting the plasticity and heterogeneity of cancer-associated fibroblasrs (CAF) during cholangiocarcinogene...
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Cancer Stem Cells in intrahepatic cholangiocarcinoma
Combining in vitro and in vivo systems with high throughput transcriptomics and bioinformatics, we aim to elucidate the functional role of cancer s...
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Tracing Intra-Tumoral Heterogenenity
Tumors are highly heterogeneous entities, and we are interested in investigating the interactions between heterogeneous cancer cells and the tumor...
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Respiratory biophysics and bioengineering
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Applied research in infectious respiratory diseases and critically ill patients
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Translational research in pulmonary vascular diseases: cell proliferation and apoptotic mechanisms in pulmonary arterial hypertension
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