Search results

• CAR-T cells for the treatment of solid tumours

  After the success of CAR-T cells in hematologic malignancies, the translation of CAR-T cells to solid tumours is the next big challenge in the fiel...

  Research – Research lines

• CAR-T cells for the treatment of hematologic malignancies

  Resistance to CD19-CAR-T cells in hematologic malignancies can appear linked to loss or downregulation of CD19 expression or an immunosuppressive t...

  Research – Research lines

• Understanding the limitations of CAR-T cells in preclinical studies

  The progress of CAR-T cells is limited by a poor understanding of how the design and signaling of these CAR proteins affect T cell efficacy and per...

  Research – Research lines

• Other cancer immunotherapies and combination treatments

  While T-cell based immunotherapies have revolutionized cancer treatment, a majority of patients fail to respond or relapse after a certain period o...

  Research – Research lines

• Development, evaluation and implementation of digital technologies in the field of mental health

  New digital technologies have opened a wide range of opportunities and challenges in the mental health field. During the last decade, our team have...

  Research – Research lines

• Critical conditions for disease onset or prognosis

  To evaluate clinical and molecular features that may condition disease onset, severity, evolution and co-morbidities. Description of the natural hi...

  Research – Research lines

• Identification of genes responsible for genetic disorders

  The strategic objective of this research line is to investigate the genetic, anatomopathological and biochemical bases, as well as the physiopathol...

  Research – Research lines

• Physiopathology of disease

  To search for the physiopatological bases of these diseases we use a combination of the classical and advanced omics technologies (metabolomics, pr...

  Research – Research lines

• Validation of models, mechanisms, and biomarkers of disease

  To confirm the pathogenicity of a certain gene or molecular mechanism, we validate cell models derived from patient to study the disease. We use fi...

  Research – Research lines

• Therapeutic approaches

  This line involves the testing of chemical and peptide libraries, as well as genetic edition strategies. Selection has been made on disease-causing...

  Research – Research lines

• Ras GTPases: regulation and new roles in tumorigenesis

  Ras proteins are GTPases that regulate signal transduction pathways, which control cell proliferation, differentiation, survival and apoptosis. K-R...

  Research – Research lines

• Intracellular cholesterol transport and membrane repair in lysosomal diseases

  The endolysosomal (LE/Lys) compartment is the main intracellular reservoir of cholesterol and acts as a sorting center from which cholesterol is de...

  Research – Research lines

• Cell Death, Senescence, and Cancer Precision Medicine

  Led by Dr. J. Montero.  The Montero Lab studies cell death, senescence and cancer precision medicine at the University of Barcelona's Department o...

  Research – Research lines

• Replication Stress and Autophagy in Chromosome Instability

  Led by C. Mauvezin. Genomic instability is a hallmark of tumor cells, resulting from errors in mitotic progression such as prolonged mitosis, DNA...

  Research – Research lines

• Translational research in liver cancer

  Our scientific contributions to advancing knowledge in liver cancer during the last 15 years are summarized as follows: we contributed to the class...

  Research – Research lines

• Molecular and immune classification of HCC

  The group contributed to the molecular classification of HCC (Hoshida, NEJM 2008, Chiang Cancer Research 2008) and to the generation of gene signat...

  Research – Research lines

• Identification of determinants of response to immunotherapy in HCC

  We developed an 11-gene signature able to predict response to immune checkpoint inhibitors in HCC (Haber Gastroenterology 2022). We also contribute...

  Research – Research lines

• Molecular characterization of human NASH-HCC

  We have molecularly characterized human NASH-HCC at the genomic and molecular levels (Pinyol Journal of Hepatology 2021). 

  Research – Research lines

• Identification of drivers of oncogenesis as targets for therapies in HCC

  Several studies led to the identification of Akt/mTOR pathway [Villanueva Gastroenterology, 2008), EGFR pathway (Keng, Nature Biotech 2009), IGF pa...

  Research – Research lines

• Establishment of a molecular diagnosis and classification of HCC

  Gene-set (three genes) based diagnosis of HCC reported in Llovet, Gastroenterology 2006, and included in EASL-EORTC guidelines. In addition, we pro...

  Research – Research lines