Search results

• Characterization of exosomes isolated from seminal fluid and development of clinically relevant diagnostic and prognostic biomarkers

  Exosomes contained in the seminal fluid may contribute proteins and RNAs to the sperm. Our first goal is to characterize the protein and RNA conten...

  Research – Research lines

• Characterization of epigenetic signatures in the sperm chromatin

  We have identified a non-random distribution of proteins and genes along the sperm chromatin domains which may represent epigenetic marks involved...

  Research – Research lines

• Molecular alterations in semen from couples with idiopathic infertility

  Molecular alterations at the transcriptiomic and proteomic level are analyzed in sperm and seminal plasma from couples with idiopathic infertility...

  Research – Research lines

• Genetics of endocrine disorders

  We are  studying the genetic aspects of hereditary endocrine disorders (multiple endocrine neoplasia, congenital adrenal hyperplasia and monogenic...

  Research – Research lines

• Characterization of genes involved in the familial non-syndromic differentiated thyroid carcinoma

  Differentiated familial thyroid carcinoma represents 3-9% of thyroid carcinomas. Today, the genes involved in some rare syndromic forms in which th...

  Research – Research lines

• Mechanisms involved in redifferentiation of cancer cells

  Oncogenesis is essentially a cell dedifferentiation process. Molecules that induce  cell differentiation, such as retinoic acid, have been used for...

  Research – Research lines

• Alcoholism and other addictions, and related comorbidities: new diagnosis tools and treatment

  Examples: 1) Identification of the pattern of cannabis, tobacco, and alcohol use as a function of gender and psychiatric comorbidities that predic...

  Research – Research lines

• Therapeutic use of uric acid as peroxynitrite scavenger in acute ischemic stroke

  Studies at our lab have identified the value of uric acid administration after a brain embolism and how it acts in synergy with reperfusion therapi...

  Research – Research lines

• The chemical optimization of cerebral embolectomy

  Mechanical thrombectomy (MT) increases brain reperfusion and the likelihood of good outcome in patients with acute stroke but only about one third...

  Research – Research lines

• Blood-brain barrier disruption in cerebrovascular diseases

  Blood-brain barrier (BBB) disruption is one of the major deleterious mechanisms implicated in the physiopathology of Central Nervous System disease...

  Research – Research lines

• Brain-gut cross-talk in stroke: targeting gut barrier dysfunction and immune responses to improve stroke outcome

  Infection is a frequent complication of stroke associated with mortality and poor neurological recovery. Recent experimental studies show that post...

  Research – Research lines

• Vascular changes with aging and in animal models of vascular dementia

  Vascular dementia (VaD) is recognized as one of the leading causes of cognitive impairment and dementia in the elderly, and has become one of the m...

  Research – Research lines

• Inflammatory and immune responses to stroke

  Brain cell death after acute stroke triggers inflammation, involving glial and endothelial cell activation, invasion of leukocytes to the damaged t...

  Research – Research lines

• Sphingolipid and mitochondrial oxidative-stress regulation of cell death

  The sphingolipid rehostat greases the machinery of cell death unleashing the molecular players involved in the execution of cell death in its diver...

  Research – Research lines

• Mechanisms responsible for cholesterol transport to the mitochondria and role in NASH, hepatocellular carcinoma and Alzheimer’s disease

  As cholesterol is a major determinant of the structural properties of membrane bilayers, we aimed to understand the mechanisms underlying the intra...

  Research – Research lines

• Translational research in nonalcoholic steatohepatitis (NASH): development of NASH in a humanized mouse model to identify potential targets in human NASH

  As the biology of mice and humans differ, we have developed and established a model of mice with humanized liver, which may increase the translatio...

  Research – Research lines

• Contribution of sphingolipids and cholesterol in acute liver failure

  Disect the role of the mutual regulation between sphingolipids and cholesterol in lysosomes and mitochondrial turnover in the regulation of drug in...

  Research – Research lines

• Mitochondrial cholesterol and glycosphingolipids in liver fibrosis. Reciprocal regulation between HIF1a and StARD1 in steatohepatitis and hepatocellular carcinoma

  We aimed to study the impact of mitochondrial cholesterol and glycosphingolipids in the stabilization/activation of HIF1a and its impact  in the pr...

  Research – Research lines

• ER stress-mitochondrial cholesterol axis in obesity-associated insulin resistance and comorbidities

  Our purpose is to understand the impact of mitochondrial cholesterol in adipose tissue and muscle and their interplay in insulin resistance and non...

  Research – Research lines

• Lysosomal proteases role during tissue remodeling and regeneration in liver and kidney injury

  This research line focuses on identifying new therapeutic targets for liver and kidney disease treatment by studying the cellular and molecular pat...

  Research – Research lines