Search results

• 3. Etiopathogenesis, bronchial infection and inflammation in the patient with chronic obstructive pulmonary disease (COPD

  Role of infections in exacerbation of the disease. Study of bronchial and associated systemic response. Analysis of the risk and prognostic factors...

  Research – Research lines

• 4. Chronic pulmonary infections

  Bronchiectasis not associated with cystic fibrosis, immune deficiencies and cystic fibrosis in the adult. Control of bronchial colonization. Study...

  Research – Research lines

• 5. Infectious lung complications in immune depressed patients

  Evaluation of the etiological factors. Optimization of the diagnostic techniques. Study of bronchial inflammatory and associated systemic response....

  Research – Research lines

• 6. Invasive and noninvasive mechanical ventilation

  Epidemiology, costeffectiveness and physiopathology. New techniques. Weaning from mechanical ventilation: role of the inflammatory response and res...

  Research – Research lines

• 7. Porcine model of acute pulmonary damage due to methicillinresistant P. aeruginosa, S. aureus and S. pneumoniae

  Study of new coadjuvant drugs, antibiotics and therapies for pneumonia, prevention of ventilator-associated pneumonia (VAP), and new forms of mecha...

  Research – Research lines

• 8. Translational research laboratory for the microbiology diagnosis and pathogen-host response in respiratory infections

  Respiratory microbiome, advanced and rapid microbiology diagnostic, biofilm associated acute and chronic respiratory infections, advanced imaging i...

  Research – Research lines

• 9. Chronic sleep apnea

  Chronic sleep apnea models Multicenter Study to assess the effect of CPAP on cardiovascular diseases in patients with sleep apnea Telematic c...

  Research – Research lines

• Systemic lupus erythematosus, antiphospholipid syndrome and systemic sclerosis

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Clinical trials in new biological t...

  Research – Research lines

• Sjögren’s syndrome, autoimmune manifestations of hepatitis C virus infection and biological therapies

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Study of IgG4 disease associated wi...

  Research – Research lines

• 1. CAR-T and CAR-NK therapy for the treatment of hematological malignancies

  Directed by Álvaro Urbano Preclinical development of CARs for the treatment of malignant diseases. Specifically, we have developed a CAR against B...

  Research – Research lines

• The neural circuitry of expectation during decision making tasks

  In this project, funded by the European Research Council (ERC-2015-CoG - 683209_PRIORS), we aim to characterize the neural basis of expectation, an...

  Research – Research lines

• The dynamics of sensory evidence integration during perceptual decision making

  During perceptual discrimination task sensory information must be transformed into decision evidence and then temporally integrated in order to yie...

  Research – Research lines

• The neural circuitry of Working Memory (WM): memory interference and disease-mediated deficits

  Working memory is the cognitive function describing the maintenance and processing of information in the brain during brief periods of time. The br...

  Research – Research lines

• 2. CAR-T cell therapies for solid tumours

  Directed by Álvaro Urbano We are developing novel CAR-T cell therapies for the treatment of solid tumours, with a primary focus on breast and ovar...

  Research – Research lines

• 3. Mechanisms of antitumor cytotoxicity of immune cells (NK and T lymphocytes)

  Directed by Álvaro Urbano We use both NK cells and CAR-NK cells to increase the activity of CART cells avoiding CART cell exhaustion and increasin...

  Research – Research lines

• 4. Allogeneic stem cell transplantation: graft versus host disease (GVHD) and Infectious complications

  Directed by Álvaro Urbano GVHD and Infectious complications are the main problems occurring after allogeneic stem cell transplantation, being resp...

  Research – Research lines

• Study of the molecular mechanisms involved in the development of bleeding and thrombotic disorders

  Our group’s scientific trajectory is focused on the study of the mechanisms involved in the development of haemorrhagic pathologies, particularly t...

  Research – Research lines

• Characterization of endothelial dysfunction in association with different pathological situations

  Some diseases have a high cardiovascular risk, such as chronic kidney failure, diabetes, and obesity, among others, in which we surmise that endoth...

  Research – Research lines

• Search for biomarkers of graft-versus-host disease (GvHD)

  We have identified certain endothelial damage in the context of transplanted haematopoietic progenitor cells in patients. The behaviour of these ma...

  Research – Research lines

• Diagnosis and treatment of thrombotic microangiopathies

  Thrombotic microangiopathies (TMAs) have matching symptoms but may be due to quite different causes. Differential diagnosis of thrombotic thrombocy...

  Research – Research lines