Search results

• Development of predictive models recapitulating tumor heterogeneity and their impact on disease evolution, therapy resistance and susceptibility to novel targeted therapies

  Due to the high heterogeneity and complexity of B lymphoid malignancies, the analysis of the effect of novel targeted drugs in different mutational...

  Research – Research lines

• Mechanisms of resistance to targeted therapy

  Treatment with novel targeted drugs like the Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib or the Bcl-2 antagonist venetoclax improved outcome...

  Research – Research lines

• Prevention and treatment of chronic liver diseases

  Directed by Pere Ginès This line focuses on risk factors and early diagnosis of chronic liver diseases in the general population. It defines liver...

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• Pathogenic mechanisms of alcohol-related liver disease, effects of abstinence, and novel therapies

  Directed by Elisa Pose This established line combines clinical and translational research on alcohol-related liver disease. It includes independen...

  Research – Research lines

• Mechanisms of disease progression and risk stratification in metabolic dysfunction-associated steatotic liver disease

  Directed by Isabel Graupera This line studies how metabolic dysfunction drives MASLD progression and supports risk stratification for personalized...

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• Translational liver cell biology and disease mechanisms in chronic liver disease

  Directed by Mar Coll This translational line focuses on liver inflammation and cellular mechanisms underlying chronic liver disease progression. I...

  Research – Research lines

• Sleep and sleep disorders

  A clinical and electrophysiological assessment of normal sleep in humans and of sleep disorders including the anti-IgLON5 disease, REM sleep behavi...

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• Epilepsy

  Characterization of the epileptogenic activity and the surgical and medical therapy of the refractory epilepsy using functional MRI, video-EEG and...

  Research – Research lines

• Neuropathic pain

  Electrophysiological evaluation of the neuropathic pain using nocioceptive evoked potentials and other tools including the startle reaction.

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• Motor control

  Assesment of the motor control in healthy subjects and in patients with neurological diseases using acoustic and somatosensorial stimul and prepulse.

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• Precision screening, diagnosis, and staging for enhanced liver cancer outcomes

  Directed by Maria Reig  Effective stratification of patients according to their cancer risk is essential to ensure cost-effective screening progra...

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• Non-invasive prognostic assessment by radiology in liver cancer

  Directed by Jordi Rimola   It is necessary to identify the radiological imaging biomarkers that have the potential to provide valuable prognostic...

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• Predictive factors of treatment response in liver cancer

  Directed by Maria Reig  This research line focuses on identifying and understanding key predictive factors that influence the response to surgical...

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• Nanomedicine, cell therapy, and tissue engineering in liver diseases

  Directed by Pedro Melgar-Lesmes We investigate molecular targets in each hepatic cellular compartment involved in liver disease pathophysiology to...

  Research – Research lines

• Multi-omics research in newborn screening, diagnosis, and treatment of rare diseases

  Directed by Judit García-Villoria Translational research in rare diseases, particularly inherited metabolic disorders, based on multi-omics strate...

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• Translational application of nanozymes in liver and metabolic diseases

  Directed by Gregori Casals Mercadal We investigate the translational application of cerium- and gold-based nanoenzymes in steatotic liver disease...

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• Research and validation of non-invasive biomarkers and antifibrotic strategies

  Directed by Manuel Morales-Ruiz This line centers on the research and clinical validation of non-invasive serological markers for liver injury and...

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• Establish new therapies for liver regeneration and the normalisation of the intrahepatic vasculature in cirrhotic livers

  Directed by Manuel Morales-Ruiz This research area focuses on developing innovative therapies to restore liver regeneration and normalize intrahep...

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• Translational research in rare genetic disorders

  Directed by Manuel Morales-Ruiz This research area focuses on the study of rare hereditary genetic disorders and neurodevelopmental conditions, in...

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• Basic and translational research

  Immuno-pathogenesis of HIV infection and mechanisms of HIV control Generation of new immunogens based on defective HIV-based vectors  Developme...

  Research – Research lines