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We are using RNAi strategies in vivo in order to modulate the expression of genes involved in the pathophysiology and treatment of major depressive...
Using models of AAV vector-induced overexpression or of RNAi-induced knockdown of α- and γ-synucleins, we are studying their physiological role in...
As a general objective of the group, we aim at identifying the brain circuits involved in the therapeutic action of drugs used to treat major depre...
Studies investigating the molecular mechanisms underlying the inflammatory process commonly observed in chronic liver disease.
The following lines are mainly focussed on clinical and diagnostic features of HIV & co-infection: HCV and HBV coinfection. Efficacy and safety...
Pharmacogenomics and pharmacokinetics Opportunistic diseases associated to HIV infection: tuberculosis, human papillomavirus, anal cancer Sol...
When several diseases coexist in the same patient (comorbidities), care management becomes substantially more complex. In general, there is a growi...
In Spain, which has high life expectancy, an aging population, and universal health care free at the point of use, both the number of persons with...
The elderly population will increase in forthcoming decades, making frailty an increasing public health problem. There is evidence of the benefit o...
Irrational use of medicines is a major problem worldwide. WHO estimates that more than half of all medicines are prescribed, dispensed or sold inap...
Systemic autoimmune diseases (SADs) are a significant cause of morbidity and mortality worldwide, although their epidemiological profile varies sig...
Hypertension (HT), smoking, and hypercholesterolemia are the three most common cardiovascular risk factors in Spain. Prevalence of HT in adults > 1...
Chronic widespread pain (CWP) is a health problem worldwide, with a reported prevalence ranging from 4.2% to 13.3%. The multifaceted reality of CWP...
Cigarette smoking is the leading preventable cause of death in many countries. Moreover, smokers are more likely than nonsmokers to develop heart d...
Respiratory diseases are a common health problem. Many times, people are genetically more likely to get respiratory conditions, but work place or e...
Digestive and liver diseases are associated with substantial morbidity and mortality in many countries. Statistics about the incidence, prevalence,...
The WHO estimates that one-third of patients with HIV infection in Europe are undiagnosed. This leads to transmission of the infection, late diagno...
The widespread of mobile smartphones among the population has resulted in a growing range of mobile applications in health using iOS and Android de...
Directed by Marc Claret We have an original line of research exploring the complex interplay between feeding behavior, stress, emotions, and soci...
Diabetes is a serious global health problem due to its prevalence (more than 425 million people), the economic burden and the number of deaths it c...