Search results

• Study of the structure and function of the SLAM leukocyte molecules and their role in autoimmunity and cancer

  The SLAM receptors belong to a family of molecules expressed on lymphocytes and other leukocytes. We and other research has demonstrated that they...

  Research – Research lines

• Study of the structure and function of scavenger-like receptors and their role as inmunomodulators in infection, autoimmunity and cancer

  The Scavenger Receptor Cysteine-Rich Superfamily (SRCR-SF) is an ancient and highly conserved group of immune cell receptors involved in the develo...

  Research – Research lines

• Study of citomegalovirus (CMV) modulation of the immune response and viral immune evasion strategies

  Viruses have developed during their coevolution with their host powerful mechanisms of immune evasion. We are identified and describe the function...

  Research – Research lines

• Mechanisms of progression in monoclonal gammopathies

  Only 10% of patients with monoclonal gammopathy of undetermined significance (MGUS) ultimately develop multiple myeloma (MM) while eventually all p...

  Research – Research lines

• Real life data

  In our data base we have included the 1384 patients diagnosed and followed at our institution since 1970. We are in the process of the analysis of...

  Research – Research lines

• Extramedullary involvement in multiple myeloma

  The extramedullary involvement in multiple myeloma is associated with a poor response to therapy and to a shortened survival. Our group is largely...

  Research – Research lines

• Cardiac involvement in AL amyloidosis

  The degree of cardiac involvement is the critical prognostic marker in AL amyloidosis. Our institution is a reference center for this disease and o...

  Research – Research lines

• Clinical trials

  We are developing a number of clinical trials with new drugs and new drug combinations in multiple myeloma and also in AL amyloidosis. Of note, Dr....

  Research – Research lines

• 1. Epidemiology, prevention and new treatments of pneumonias associated with artificial ventilation and new methods of fast diagnosis

  Risk factors, Resistances of microorganisms. Local and systemic inflammatory response. New therapies.

  Research – Research lines

• 2. Epidemiology and diagnosis of community-acquired pneumonia

  Multicenter studies in the setting of community-acquired pneumonia. New methods for fast diagnosis. New treatments. Resistances of microorganisms....

  Research – Research lines

• 3. Etiopathogenesis, bronchial infection and inflammation in the patient with chronic obstructive pulmonary disease (COPD

  Role of infections in exacerbation of the disease. Study of bronchial and associated systemic response. Analysis of the risk and prognostic factors...

  Research – Research lines

• 4. Chronic pulmonary infections

  Bronchiectasis not associated with cystic fibrosis, immune deficiencies and cystic fibrosis in the adult. Control of bronchial colonization. Study...

  Research – Research lines

• 5. Infectious lung complications in immune depressed patients

  Evaluation of the etiological factors. Optimization of the diagnostic techniques. Study of bronchial inflammatory and associated systemic response....

  Research – Research lines

• 6. Invasive and noninvasive mechanical ventilation

  Epidemiology, costeffectiveness and physiopathology. New techniques. Weaning from mechanical ventilation: role of the inflammatory response and res...

  Research – Research lines

• 7. Porcine model of acute pulmonary damage due to methicillinresistant P. aeruginosa, S. aureus and S. pneumoniae

  Study of new coadjuvant drugs, antibiotics and therapies for pneumonia, prevention of ventilator-associated pneumonia (VAP), and new forms of mecha...

  Research – Research lines

• 8. Translational research laboratory for the microbiology diagnosis and pathogen-host response in respiratory infections

  Respiratory microbiome, advanced and rapid microbiology diagnostic, biofilm associated acute and chronic respiratory infections, advanced imaging i...

  Research – Research lines

• 9. Chronic sleep apnea

  Chronic sleep apnea models Multicenter Study to assess the effect of CPAP on cardiovascular diseases in patients with sleep apnea Telematic c...

  Research – Research lines

• Systemic lupus erythematosus, antiphospholipid syndrome and systemic sclerosis

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Clinical trials in new biological t...

  Research – Research lines

• Sjögren’s syndrome, autoimmune manifestations of hepatitis C virus infection and biological therapies

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Study of IgG4 disease associated wi...

  Research – Research lines

• 1. CAR-T and CAR-NK therapy for the treatment of hematological malignancies

  Directed by Álvaro Urbano Preclinical development of CARs for the treatment of malignant diseases. Specifically, we have developed a CAR against B...

  Research – Research lines