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• 4. Expanding indications for transplantation for malignant tumors – hilar cholangiocarcinoma and colorectal cancer liver metastases

  The decrease in the number of patients on liver transplant waiting lists due to the advent of effective treatment for hepatitis C virus has generat...

  Research – Research lines

• 5. Alloimmune response, complications associated with immunosupression, and operational tolerance

  Treatment with immunosupression is associated with a series of risks for the transplanted patient, making minimization key to optimizing post-trans...

  Research – Research lines

• 6. Prevention and treatment of cardiovascular risk factors following liver transplantation

  Cardiovascular diseases represent one of the most common causes of long-term morbidity and mortality after liver transplantation. This group focuse...

  Research – Research lines

• Clinical applicability of genomic copy-number alterations and aneuploidy

  Chromosomal aneuploidy results in the acquisition of copy-number alterations, which occur early in tumorigenesis and are positively selected throug...

  Research – Research lines

• Intratumor heterogeneity as a novel biomarker in colorectal cancer

  Elucidating the role of genomic instability, which represents the molecular engine that fuels intratumor heterogeneity in carcinomas, is critical f...

  Research – Research lines

• Functional consequences of whole-genome doubling and its impact on disease outcome

  There is growing evidence that whole-genome doubling occurs early in tumorigenesis and triggers genetically unstable near-tetraploid cells. In addi...

  Research – Research lines

• 1-Which is the role of translational control of gene expression in liver disease and cancer?

  To understand the molecular mechanisms involved in the development and progression of liver disease and cancer, with a focus on the aberrant reprog...

  Research – Research lines

• 2-What is the significance and underlying mechanisms linking obesity with liver disease and cancer?

  To decipher mechanisms underpinning the detrimental impact of obesity in liver disease and cancer. This knowledge is crucial for advancements in tr...

  Research – Research lines

• 3-How does deregulation of pathways that control angiogenesis contribute to progression of liver disease and cancer?

  To define the molecular and cellular mechanisms that regulate/dysregulate angiogenesis in liver disease and cancer and define their functional rele...

  Research – Research lines

• Autoantibody-driven neurodegeneration and demyelination

  Directed by Lidia Sabater Our research focuses on how pathogenic autoantibodies drive neurodegenerative and demyelinating disorders, including ant...

  Research – Research lines

• Translational research in pediatric neuroimmunology

  Directed by Thaís Armangue This research focuses on autoimmune and inflammatory neurological diseases in children, identifying novel antigens in a...

  Research – Research lines

• Advanced Therapies

  Coordination of the transfer of basic research in advanced therapies from the Hospital Clínic to its clinical application, through the scientific e...

  Research – Research lines

• Pharmacovigilance

  Research on the molecular and pathophysiological mechanisms of adverse drug reactions and implementation of active pharmacovigilance systems that a...

  Research – Research lines

• Support to clinical research: Design, methodology, regulatory, project management, monitoring, data management and statistics

  Optimization of methodological and statistical support for clinical research and full-service CRO for phase I-IV clinical trials sponsored by acade...

  Research – Research lines

• Ethics in clinical research

  Search for quality and the extent and context of application of current ethical principles in clinical research projects. It is developed in group...

  Research – Research lines

• Pharmacogenetics and pharmacogenomics

  Development of studies to relate genetics with the activity and response to the action of drugs.

  Research – Research lines

• Coordination of multinational projects and research networks

  Active collaboration in national clinical research networks, such as SCReN (Spanish clinical Research Network), to carry out multicenter clinical r...

  Research – Research lines

• Etiopathogenesis in endometriosis and adenomyosis

  Directed by: Maria Angels Martínez Zamora To evaluate new insights in the knowledge of the origin and recurrence of endometriosis and adenomyosis...

  Research – Research lines

• Human papillomavirus (HPV) infection and prevention

  Directed by: Marta del Pino To understand the natural history of HPV infection will allow us to improve both prevention strategies and related les...

  Research – Research lines

• Elimination and biomarkers in viral hepatitis

  Directed by Sabela Lens We develop integrated micro-elimination strategies for viral hepatitis (HBV/HDV/HCV) within the Hospital Clínic area and t...

  Research – Research lines