Search results

• Glutamatergic signalling: functional interaction between AMPARs, auxiliary subunits and novel interacting proteins

  Physiological characterization of AMPAR and interacting proteins (TARPs and CPT1C) in neurons and glial cells and the role in memory and sensibilit...

  Research – Research lines

• Pathophysiology of the NMDAR receptor and personalised medicine for GRIN-related disorders.

  Functional studies of NMDAR receptors with new block synthesis compounds and positive allosteric modulators in the framework of neurological diseases.

  Research – Research lines

• Ocular physiology: dry eye physiopathology and sensory neurons on the ocular surface. Pathophysiology of the drainage of aqueous humour and the physiopathology of glaucoma

  Study of the ionic channels involved in the detection of painful and irritating stimuli on the ocular surface and its role in eye pathologies such...

  Research – Research lines

• Physiology and pathophysiology of pain and chronic itch. Study of the ion channels involved in neuronal excitability in the sensory nervous system

  Study of the ionic channels that regulate the electrical activity of sensory neurons and how they are altered during the pathology. Identification...

  Research – Research lines

• Microglia-neuron crosstalk in health and disease

  To understand how neuron-glia communication contributes to synapse and neuronal loss, and modulates neuronal activity in neurodegeneration. A majo...

  Research – Research lines

• N-glycosilation channelopathies and synaptic function

  Investigation how the activity of synaptic proteins and the synaptic function is affected by physiological and pathological N-glycosylation and its...

  Research – Research lines

• Utility of ECG imaging in locating abnormal conduction zones and in mapping arrhythmias.

  This involves obtaining images of the heart’s electrical activity in a noninvasive manner in order to apply this knowledge to developing ablation s...

  Research – Research lines

• Role of stimulation of the conduction system in cardiac stimulation.

  Study of new physiologic stimulation techniques. Assessment of results and complications. 

  Research – Research lines

• Study of the utility of new mapping tools in ablation of ventricular tachycardia

  Treatment of ventricular tachycardia requires detailed mapping of the circuits. Currently, catheters are used that are more accurate than is requir...

  Research – Research lines

• Biomarkers, transplant immunology and cell therapy in renal and pancreatic transplantation.

  Directed by Dr. Fritz Diekmann and Dr. Pedro Ventura In the last years we have worked with exosomes, Chimeric antigen receptor-T cells (CAR-Ts), M...

  Research – Research lines

• New technologies and biomarkers in dialysis

  Directed by Dr. Francesc Maduell During the last years we analyzed and improved the quality of dialysis, especially studying vascular calcificatio...

  Research – Research lines

• Pathophisiology and innovative therapies in acute and chronic kidney disease

  Directed by Dr. Luis F Quintana and Dr Miquel Blasco. We were studying endothelial dysfunction and complement disorders in the context of chronic...

  Research – Research lines

• Artificial intelligence

  Directed by Dr. Ignacio Revuelta We are developing predictive AI models that classify patients in terms of their immunological risk and, consequen...

  Research – Research lines

• Immune response in hepatitis B and D

  Directed by Sabela Lens We investigate the mechanisms of the immune response in chronic HBV and HDV infection to identify determinants of viral co...

  Research – Research lines

• Autoimmune and cholestatic liver diseases

  Directed by Maria Carlota Londoño Research focuses on autoimmune and cholestatic liver diseases, including autoimmune hepatitis, primary biliary c...

  Research – Research lines

• Epidemiology of drug-induced liver injury and Wilson’s disease

  Directed by Xavier Forns We analyze the epidemiology and clinical impact of drug-induced liver injury (DILI), including medications, herbals, and...

  Research – Research lines

• CAR-T cells for the treatment of solid tumours

  After the success of CAR-T cells in hematologic malignancies, the translation of CAR-T cells to solid tumours is the next big challenge in the fiel...

  Research – Research lines

• CAR-T cells for the treatment of hematologic malignancies

  Resistance to CD19-CAR-T cells in hematologic malignancies can appear linked to loss or downregulation of CD19 expression or an immunosuppressive t...

  Research – Research lines

• Understanding the limitations of CAR-T cells in preclinical studies

  The progress of CAR-T cells is limited by a poor understanding of how the design and signaling of these CAR proteins affect T cell efficacy and per...

  Research – Research lines

• Other cancer immunotherapies and combination treatments

  While T-cell based immunotherapies have revolutionized cancer treatment, a majority of patients fail to respond or relapse after a certain period o...

  Research – Research lines