Search results

• 8. Translational research laboratory for the microbiology diagnosis and pathogen-host response in respiratory infections

  Respiratory microbiome, advanced and rapid microbiology diagnostic, biofilm associated acute and chronic respiratory infections, advanced imaging i...

  Research – Research lines

• 9. Chronic sleep apnea

  Chronic sleep apnea models Multicenter Study to assess the effect of CPAP on cardiovascular diseases in patients with sleep apnea Telematic c...

  Research – Research lines

• Systemic lupus erythematosus, antiphospholipid syndrome and systemic sclerosis

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Clinical trials in new biological t...

  Research – Research lines

• Sjögren’s syndrome, autoimmune manifestations of hepatitis C virus infection and biological therapies

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Study of IgG4 disease associated wi...

  Research – Research lines

• 1. CAR-T and CAR-NK therapy for the treatment of hematological malignancies

  Directed by Álvaro Urbano Preclinical development of CARs for the treatment of malignant diseases. Specifically, we have developed a CAR against B...

  Research – Research lines

• The dynamics of evidence integration during decision making

  Directed by Jaime de la Rocha We study how information, acquired from sensation or from previous experiences, is transformed into decision variabl...

  Research – Research lines

• The neural circuitry of Working Memory (WM): memory interference and disease-mediated deficits

  Directed by Jaime de la Rocha We study how the brain maintains and uses information over short periods (working memory) using behavioral tasks in...

  Research – Research lines

• Midbrain circuitry mediating instrumental learning

  Directed by Hernando Martinez Vergara The Basal Ganglia (BG) are critical for learning, allowing vertebrates to adapt their behavior to maximize u...

  Research – Research lines

• 2. CAR-T cell therapies for solid tumours

  Directed by Álvaro Urbano We are developing novel CAR-T cell therapies for the treatment of solid tumours, with a primary focus on breast and ovar...

  Research – Research lines

• 3. Mechanisms of antitumor cytotoxicity of immune cells (NK and T lymphocytes)

  Directed by Álvaro Urbano We use both NK cells and CAR-NK cells to increase the activity of CART cells avoiding CART cell exhaustion and increasin...

  Research – Research lines

• 4. Allogeneic stem cell transplantation: graft versus host disease (GVHD) and Infectious complications

  Directed by Álvaro Urbano GVHD and Infectious complications are the main problems occurring after allogeneic stem cell transplantation, being resp...

  Research – Research lines

• Study of the molecular mechanisms involved in the development of bleeding and thrombotic disorders

  Our group’s scientific trajectory is focused on the study of the mechanisms involved in the development of haemorrhagic pathologies, particularly t...

  Research – Research lines

• Characterization of endothelial dysfunction in association with different pathological situations

  Some diseases have a high cardiovascular risk, such as chronic kidney failure, diabetes, and obesity, among others, in which we surmise that endoth...

  Research – Research lines

• Search for biomarkers of graft-versus-host disease (GvHD)

  We have identified certain endothelial damage in the context of transplanted haematopoietic progenitor cells in patients. The behaviour of these ma...

  Research – Research lines

• Diagnosis and treatment of thrombotic microangiopathies

  Thrombotic microangiopathies (TMAs) have matching symptoms but may be due to quite different causes. Differential diagnosis of thrombotic thrombocy...

  Research – Research lines

• Evaluation of the physiological and pathological implications of circulating and/or platelet associated procoagulant microparticles in atherothrombosis

  Platelet-derived microparticles facilitate interaction with other cell groups and may have a prothrombotic effect in certain pathological situation...

  Research – Research lines

• Clinical cohorts of prodromal & established disease

  We have built unique prospective cohorts for the clinical and biological characterization of at-risk and prodromal Parkinson’s disease cohorts, e.g...

  Research – Research lines

• Novel diagnostic & prognostic biomarkers

  We seek, set-up and introduce clinically meaningful biomarkers. Hence, we pioneered the alpha-synuclein seed amplification assay in CSF, being the...

  Research – Research lines

• Innovative tissue & cellular models of disease

  We investigate the pathophysiological mechanisms and pathways to unravel novel therapeutic targets of neurodegenerative movement disorders using hu...

  Research – Research lines

• 1. Deep phenotyping of pulmonary hypertension in chronic respiratory diseases

  Our group is currently investigating the endogenous phenotype that determines the heterogeneity of pulmonary hypertension in chronic airway obstruc...

  Research – Research lines