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Regulación mitocondrial de la muerte celular y la esteatohepatitis

Líneas de investigación

  • Lipids as intracelular messengers in disease

    Directed by Jose Carlos Fernández-Checa

    Lipids act as structural molecules, energy sources and signalling factors. Our work has focused on lipid interactions at cellular and subcellular levels in liver diseases, identifying a key role for StARD1 in mitochondrial dysfunction and alternative bile acid synthesis, influencing cell death, inflammation and carcinogenesis. StARD1 is also implicated in neurodegenerative and lysosomal diseases. We are developing strategies to counteract its effects in DILI, MASH-HCC, AD and NPC.

  • Lipid cell biology and its impact on metabolic liver disease

    Directed by Carmen Garcia-Ruiz

    The team research efforts aim to understand the homeostasis and trafficking of cholesterol and sphingolipids in the progression of MAFLD. We described for the first time that the type rather than the amount of fat in hepatocytes is a critical determinant in the transition from steatosis to steatohepatitis, and that enhanced hepatic free cholesterol levels correlates with disease progression in patients. We aim to identify the underlying mechanisms involved and design strategies with therapeutic potential.

  • Molecular targets of cancer

    Directed by Pilar Navarro

    Our research focuses on the molecular mechanisms driving tumor progression, with emphasis on pancreatic cancer, tumor-stroma interactions, and gene expression regulation. We identify and validate novel molecular targets, including Galectin-1, CPEB4, AXL, and PARP2, using patient samples and preclinical models. Our ultimate goal is to develop biomarker- and target-driven strategies aiming to advance early diagnosis and precision medicine in this highly aggressive disease.

  • Tissue remodeling, fibrosis and cancer

    Directed by Anna Moles

    Our research investigates tissue remodeling during the onset, progression, and resolution of chronic diseases, with a focus on fibrosis and cancer, both serious life-threatening conditions. We study the cellular and molecular mechanisms that govern the complex interplay between tissue-resident cells, the stroma, and the extracellular matrix, with the aim of identifying novel therapeutic targets to prevent, slow, or reverse fibrosis and cancer.

  • Inflammasome activation and mitochondrial stress in the progression of MAFLD to hepatocellular carcinoma and DILI

    Directed by Sandra Torres

    We study the progression of MAFLD to hepatocellular carcinoma and drug-induced liver injury (DILI), with special attention to the role of mitochondrial stress and NLRP3 inflammasome activation. We investigate how mitochondrial dysfunction links chronic inflammation, cellular damage, and tumorigenesis. Using experimental models and human samples, we aim to identify biomarkers and therapeutic targets to improve diagnosis and treatment.