New pharmacological approaches to interfere in the Marfan syndrome-associated TGF-β hypersignaling
We use TGF-β receptor peptide sequences to sequester soluble active TGF-β in excess to prevent the aortic aneurysm.
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We use TGF-β receptor peptide sequences to sequester soluble active TGF-β in excess to prevent the aortic aneurysm.
We aim to characterize the myocardial and electrical substrate in patients with atrial fibrillation and ventricular tachycardia in order to improve...
We aim to quantify and precisely describe underlying abnormalities in cardiac mechanics that could be corrected to improve the outcomes of patients...
We aim to establish non invasive risk biomarkers based on imaging and blood tests to identify subjects that will develop atrial fibrillation in ord...
We aim to characterize myocardial scar and cardiac remodelling to improve our identification of patients who will develop malignat ventricular arrh...
We aim to characterize cardiac remodelling in response to exercise training and to identify those atletes at risk of presenting sudden death. Also,...
We aim to perform a in-depth myocardial characterization of hypertrophic cardiomyopathy: comprehensive multimodality imaging, tissue characterizati...
We aim to understand the changes in valvular geometry and cardiac performance before and after implantation of novel percutanoeusly implanted devic...
We explore the additive diagnostic value of several non-invasive cardiac imaging modalities for the identification of acute coronary syndrome among...
The loss of neuronal synapses is a phenomenon that occurs in the early stages of neurodegenerative disorders. We hypothesize that synaptic neurodeg...
Ab accumulation is a primary step of Alzheimer’s disease (AD). Noteworthy, while in early-onset familial AD increased Ab burden mainly results from...
Neuroinflammation is a key pathological feature of Alzheimer’s disease (AD) that results primarily from the presence of chronically activated micro...
Directed by Immaculada Baeza The research line has been active for the last fourteen years. Both diseases are considered neurobiological disorder...
Directed by Immaculada Baeza Our group has studied clinical, neuropsychological and brain alterations in adolescents diagnosed with these disorde...
Directed by Luisa Lázaro We study patients’ neuroimaging and genetic characteristics in order to differentiate endophenotypes and also use machin...
Directed by Immaculada Baeza Our group has published studies on cognitive and neuroimaging abnormalities in ASD children and adolescents and thei...
p27 (Kip1), a classical inhibitor of cyclin dependent kinases, is also a transcriptional regulator. We are analysing the mechanisms by which p27 re...
Our research focuses on identifying the molecular mechanism by which the CaMK family regulate cell cycle control and stress response. We are actual...
Multiple myeloma and systemic AL amyloidosis. Minimal residual disease, extramedullary involvement in myeloma, cardiac involvement in amyloidosis,...
Mechanisms of progression and control in patients with multiple myeloma. Molecular and cellular features of patients with long-lasting stable mon...