"We discovered that SOX11 activates two ways: on one hand, inhibits the differentiation of lymphoma cells blocking them mantle in a state of naive cells, and secondly, stimulates angiogenesis through PDGFA, a molecule that plays a fundamental role in tumor growth", says Amador. "If we block the two pathways we could inhibit the development of breast cancer". The next step is to test the ability of these inhibitors to block the effect of oncogenic human SOX11.
Vegliante MC, Palomero J, Pérez-Galán P, Roué G, Castellano G, Navarro A, Clot G, Moros A, Suárez-Cisneros H, Beà S, Hernández L, Enjuanes A, Jares P, Villamor N, Colomer D, Martín-Subero JI, Campo E, Amador V. SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma. Blood. 2013 Mar 21;121(12):2175-85. doi: 10.1182/blood-2012-06-438937. Epub 2013 Jan 15.