Search results

• Involvement of p27 (Kip1) in cancer progression

  p27 (Kip1), a classical inhibitor of cyclin dependent kinases, is also a transcriptional regulator. We are analysing the mechanisms by which p27 re...

  Research – Research lines

• Protein kinases in cancer

  Our research focuses on identifying the molecular mechanism by which the CaMK family regulate cell cycle control and stress response. We are actual...

  Research – Research lines

• Myeloma and other monoclonal gammapathies

  Multiple myeloma and systemic AL amyloidosis. Minimal residual disease, extramedullary involvement in myeloma, cardiac involvement in amyloidosis,...

  Research – Research lines

• Mechanisms of progression in monoclonal gammopathies

  Mechanisms of  progression and control in patients with multiple myeloma. Molecular and cellular features of  patients with long-lasting stable mon...

  Research – Research lines

• Myeloid neoplasmas

  Natural history and prognosis of chronic myeloid leukemia, myeloproliferative neoplasms, acute myeloid leukemia and myelodysplastic syndromes; prog...

  Research – Research lines

• Lymphoid neoplasms

  Lymphomas, chronic lymphocytic leukemia and the other lymphoproliferative disorders: Study of progression mechanisms of the disease, genome of CLL...

  Research – Research lines

• 1. Pathogenesis of osteoporosis and fracture development in primary biliary cholangitis and other chronic cholestatic disorders

  Based on our clinical and experimental studies on the development of osteoporosis in primary biliary cholangitis, we have confirmed its high preval...

  Research – Research lines

• 3. Osteoporosis in premenopausal women and in males. Clinical characteristics and mechanisms involved in the development of the disorder

  We have analyzed the factors associated with the development of osteoporosis in men and in premenopausal women. These studies are important because...

  Research – Research lines

• 2. Osteoporosis in liver transplantation

  For years we studied the characteristics of the bone pathology in patients before and after liver transplant. We recently evaluated whether the bon...

  Research – Research lines

• 4. Evaluation of bone remodelling regulators in the pathogenesis of osteoporosis

  We have analyzed the OPG/RANKL system in different conditions: chronic cholestasis and patients with spinal cord injury. We have also analyzed aspe...

  Research – Research lines

• 5. Biomarkers in Paget disease

  For years we have studied the effectiveness of the use of bone turnover markers to analyze the activity of Paget's bone disease. We recently extend...

  Research – Research lines

• Lung development and ageing as key pathogenic determinants of adulthood respiratory diseases

  Co-directed by Dr. Alvar Agusti and Rosa Faner  We aim to understand the different respiratory diseases from a life-long perspective (Agusti, Fane...

  Research – Research lines

• Chronic Obstructive pulmonary disease (COPD) clinical complexity and heterogeneity

  Directed by Dr. Alvar Agusti   The evidence that COPD may originate early in life opens new opportunities for prediction, prevention, personalised...

  Research – Research lines

• Follicular lymphoma crosstalk with its immune microenvironment as a source novel targeted therapy

  Immune microenvironment is fundamental for Follicular lymphoma (FL) onset and progression. Thus, we study how FL cells shape their microenvironment...

  Research – Research lines

• Novel immunotherapeutic approaches in Non-Hodgkin Lymphoma (NHL)

  20 years ago, rituximab, the first anti-CD20 antibody, revolutionized the immunotherapy for treatment of lymphoma. More recently, subsequent lympho...

  Research – Research lines

• 3D lymphoma patient derived primary cultures: a superior in vitro system for personalized medicine

  In order to obtain meaningful in vitro results and increase the success of bench-to-bedside translation, robust, reliable and reproducible in vitro...

  Research – Research lines

• Functional characterization of oncogenic mechanisms in lymphomagenesis

  The objective of the group is to identify and characterize the functional role of new candidates and signaling pathways, in both cancerous and norm...

  Research – Research lines

• Best practices

  Clinical research to evaluate or improve health practice. It is important to adhere to improved code of conduct and the highest standards to get op...

  Research – Research lines

• Safety

  Interventions to promote safety and quality of care at all levels. Creating a safe environment is a top quality feature.

  Research – Research lines

• Cronicity

  Training and emotional support programs for dependant older people and their family caregivers. Development of guides and access to an online patie...

  Research – Research lines