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A non-complicated Parkinson’s disease with a good prognosis, does not shorten life expectancy. The main factors that determine a poor short-term prognosis, including an increase in mortality in the advanced disease phase, are severe dysphagia, dementia, or frequent falls with fractures.
The most common acute complications of the treatment (whether due to an increase or a reduction) are:
Hyperpyrexia Syndrome- Parkinsonism syndrome triggered by a reduction in the medication dose. It can occur more during heatwaves, and includes a significant worsening of motor symptoms, with a high fever, and muscle rigidity. It is treated with dopamine and muscle relaxants.
Missing, loss or cessation of movement (akinesia) acute. It is caused by infections or by heat and is recoverable with a boost of the treatment.
Involuntary movement disorder (dyskinesia) attacks due to a dose increase or due to the effect of deep brain stimulation.
Dopaminergic agonist withdrawal syndrome (DAWS) when this type of drug is reduced or withdrawn, it can appear very similar to that of a withdrawal syndrome of substance abuse.
All these symptoms are usually rare and can be treated medically.
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Substantiated information by:
Almudena Sánchez Gómez
Ana Cámara Lorenzo
Maria José MartíHead of the Parkinson's and Movement Disorders Unit
Yaroslau Compta Hirnyj
Published: 8 July 2019
Updated: 14 November 2019
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