What is Frontotemporal Dementia?

Reading time: 2 min

Frontotemporal dementia is a group of neurodegenerative diseases that cause a progressive loss of neurons in the nervous system. In frontotemporal dementia, these neurons are mainly lost in the frontal and lateral parts of the brain, known as the frontal and temporal lobes.

Frontotemporal Dementia in first person

Professionals and patients explain how you live with the disease
Frontotemporal dementia | PortalCLÍ...
Frontotemporal dementia is currently considered a rare disease, probably also because it may be under-diagnosed.
Frontotemporal dementia in first pe...
What I would say, above all, is live in the moment; look for all the tools that are feasible to get so you can cope.

The brain's frontal and temporal lobes are responsible for our social, executive and linguistic cognitive functions. This is why frontotemporal dementia is characterised by symptoms such as changes in personality and difficulties with language.

Types of Frontotemporal Dementia

Frontotemporal dementias can be classified based on the symptoms of the disease, such as behavioral problems and/or language problems (aphasia). There are three clinical forms of frontotemporal dementia:

  • Behavioural variant frontotemporal dementia. This is the most common form of frontotemporal dementia. It involves changes in the patient's personality, behaviour and emotions. Patients may exhibit socially inappropriate behaviour, lack of inhibition, apathy and loss of empathy. Some patients also develop ritualistic behaviours and change their food preferences, especially towards sweet foods. It also affects the executive functions of the brain, that is, those involved in planning, judgement and problem-solving. 
  • Non-fluent/agrammatic variant of primary progressive aphasia. This is a neurological condition that affects the ability to speak and express oneself correctly. People suffering from this condition have difficulty producing words and sentences because the brain has difficulty coordinating the necessary movements to speak. This is not due to a muscular problem, but a disorder in how the brain plans these movements. In general, people with this variant can understand what others say, but find talking to be increasingly difficult and, over time, their sentences become shorter and simpler. They often have trouble forming grammatically correct sentences, and may avoid words they fail to pronounce well. 
  • Semantic variant primary progressive aphasia. This is characterised mainly by a loss of semantic knowledge, that is, the meaning of concepts. This leads to patients having problems with understanding words and recognising objects or people. 

How many people is affected by Frontotemporal Dementia?

Frontotemporal dementias are a rare cause of dementia. It is estimated that 1 in 10 cases of dementia are due to frontotemporal dementia.

Unlike other forms of dementia, such as Alzheimer's disease, frontotemporal dementias tend to present at younger ages. In this sense, frontotemporal dementias are the second most common cause of dementia in patients under 65 years. Its appearance at such young ages has a huge emotional, social and economic impact on patient families.

Substantiated information by:

Núria Montagut Colomer
Sergi Borrego Écija

Published: 6 October 2021
Updated: 28 April 2025

The donations that can be done through this webpage are exclusively for the benefit of Hospital Clínic of Barcelona through Fundació Clínic per a la Recerca Biomèdica and not for BBVA Foundation, entity that collaborates with the project of PortalClínic.

Subscribe

Receive the latest updates related to this content.

Thank you for subscribing!

If this is the first time you subscribe you will receive a confirmation email, check your inbox

An error occurred and we were unable to send your data, please try again later.