Research lines about Chronic Kidney Failure

New drug development is one of the most dynamic areas in CKD research, with the main lines including:

• Drugs targeting key disease mechanisms, such as chronic inflammation, renal fibrosis and changes in energy metabolism.
• New sodium–glucose cotransporter 2 (SGLT2) modulators and their combination with other nephroprotective therapies.
• Aldosterone receptor antagonists with improved safety profiles.
• Experimental antifibrotic molecules aimed at preserving kidney structure and function in the long term.

These advances aim to delay CKD progression and reduce the burden of associated cardiovascular complications.

Research in renal replacement therapies is focused on improving efficacy, safety, and quality of life for people undergoing dialysis:

• Portable or semi-permanent haemodialysis systems, enabling greater autonomy and flexibility in treatment.
• Smart cyclers for peritoneal dialysis, incorporating algorithms that automatically adjust treatment according to patient characteristics and needs.
• Remote monitoring devices integrated into telemedicine platforms, allowing continuous follow-up and early detection of complications.

Projects focused on home monitoring of CKD patients using advanced digital technologies are gaining increasing importance:

• Biosensors, wearable electronic devices and mobile applications for monitoring weight, blood pressure, hydration status and fluid retention.
• Integration of data into clinical platforms, enabling continuous, personalised supervision by healthcare teams.