How is TIL therapy done?

The biopsy is performed by surgeons or radiologists and processed by laboratory technicians.

Immunology specialists supervise production until the necessary dose is obtained, at which point it is frozen.

On the day of the infusion, the frozen doses are taken to the patient's room, where they are immediately thawed in a temperature-controlled bath and infused by nursing staff.

TIL therapy involves several steps. First, the biopsy is performed by surgeons or radiologists. Once obtained, it is transported to the Immunology Service, where the sample is processed for TIL treatment. After 14 days of culture, it is preserved at a low temperature until it is infused into the patient in the Haematology Service. The patient is admitted one week in advance, since the administration of immunosuppressive therapy is necessary before administration of the TILs. The product is thawed under controlled conditions by an immunology specialist and administered to the patient.

The final TIL dose is frozen in 3x120 mL bags and administered in a single day. The infusion process between thawing and the intravenous infusion itself lasts 20-30 minutes, providing the patient does not react adversely to the medication.