What happens after I am treated with TILs?

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If the therapy works correctly, the patient will not have to be treated with TILs again. However, if the patient has a relapse, a biopsy of the new tumour must be performed. This is because the mutations (genetic changes) in this new tumour will produce different lymphocytes to those of the first treatment. However, recurrences are currently seen in very few cases.

What are potential complications?

Sample tube and antibodies for Ro (or SS-A) and La (or SS-B) test

Immune-related adverse effects: TIL therapy can cause alterations of the immune system, since a high number of T lymphocytes with PD1 expression are administered.

Cancer cell surrounded by healthy cells

Secondary tumours.

Liver sored with Antibodies Around

Autoimmune reactions.

Person vomiting in a toilet

Metallic taste, nausea, vomiting.

Hives or allergic contact dermatitis on the arm

Allergic reactions to gentamicin in some patients.

Elderly person in bed with fever

Infusion reaction resulting from administration of a blood product: fever, shivering, skin rash.

Two kidneys with a lightning bolt indicating rejection

Tumour lysis syndrome: kidney failure and dyselectrolytaemia (imbalance in levels of sodium and potassium, among others, in the blood).

Person performing repetitive arm movements

Cytokine release syndrome: including fever, nausea and many other side effects.

Substantiated information by:

Mariona Pascal Capdevila
Sergio Navarro Velázquez

Published: 21 September 2023
Updated: 21 September 2023


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