Línies de recerca

• Asymptomatic monoclonal gammopathies, extramedullary involvement in multiple myeloma, real-world outcomes and clinical trials

  Directed by Laura Rosiñol Dachs

  Clinical and biological characterization of asymptomatic gammopathies and their progression, study of extramedullary involvement mechanisms in myeloma, and real-world cohort analysis to identify patterns, prognostic factors and therapeutic opportunities. Includes design and execution of innovative multicenter clinical trials.

• CAR-T cells against BCMA in multiple myeloma: prognostic factors and development of new chimeric receptors

  Directed by Carlos Fernández de Larrea

  CAR-T therapy uses autologous T cells genetically modified. Despite efficacy, relapses occur and questions remain about its role in extramedullary disease or BCMA-negative relapse. Research focuses on sustaining CAR-T effectiveness and creating a new generation of more durable CAR-T cells.

• Cardiac involvement and targeted treatments in amyloidosis

  Directed by Carlos Fernández de Larrea

  Cardiac involvement is the main prognostic marker in AL amyloidosis. We assess the impact of combined strategies: drugs targeting plasma cells and agents removing amyloid deposits in affected organs, aiming to improve survival and treatment response.