COL·LABORA El Meu Clínic .Aquest enllaç s'obre en una nova pestanya.
COL·LABORA El Meu Clínic .Aquest enllaç s'obre en una nova pestanya.
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Trasplantament de progenitors hemopoiètics

Línies de recerca

  • 1. CAR-T and CAR-NK therapy for the treatment of hematological malignancies

    Directed by Álvaro Urbano

    Preclinical development of CARs for the treatment of malignant diseases. Specifically, we have developed a CAR against BCMA, which can be used for the treatment of mature B cell malignancies. Moreover, we study tumor cell mechanisms that impact in the CART cell activity, such as loss of the expression of the target antigen and secreted factors that can increase CART cell activity.

  • 2. CAR-T cell therapies for solid tumours

    Directed by Álvaro Urbano

    We are developing novel CAR-T cell therapies for the treatment of solid tumours, with a primary focus on breast and ovarian cancers. Studies are underway to understand the obstacles that lead to CAR-T cell treatment failure in solid tumors (including T cell exhaustion and tumour escape due to loss of antigen expression) and developing novel strategies to overcome these hurdles.

  • 3. Mechanisms of antitumor cytotoxicity of immune cells (NK and T lymphocytes)

    Directed by Álvaro Urbano

    We use both NK cells and CAR-NK cells to increase the activity of CART cells avoiding CART cell exhaustion and increasing the antileukemic activity of CARTs. Moreover, we study tumor cell death mechanisms activated by CART and NK cells in order to increase their antitumor activity while avoiding associated problems to this therapy, such as the high inflammatory response which occurs after CART cell administration.

  • 4. Allogeneic stem cell transplantation: graft versus host disease (GVHD) and Infectious complications

    Directed by Álvaro Urbano

    GVHD and Infectious complications are the main problems occurring after allogeneic stem cell transplantation, being responsible for a mortality rate associated to this procedure. We study clinical and genetic variables associated to these complications and develop clinical procedures in order to avoid them.

  • 5. Frailty in Hematopoietic Cell Transplant Candidates

    Directed by Mª Queralt Salas

    Our research studies the incidence, risk factors, and impact of frailty in adult candidates for allogeneic and autologous hematopoietic cell transplantation. We assess multidisciplinary prehabilitation and post-transplant rehabilitation to reverse frailty. In parallel, in vitro studies explore cellular and biological mechanisms, including immune, metabolic, and stress-response alterations. By combining clinical and translational approaches, we aim to improve stratification, optimize interventions, and enhance functional capacity, transplant tolerance, survival, and quality of life.