Publicacions destacades

CPEB4 deficiency promotes vasculogenic mimicry and resistance to anti-angiogenic therapy in hepatocellular carcinoma

Cardenas, Beatriz, I; Naranjo Suarez, Salvador; Baroja, Isabel; Mendez, Ana; Bosch-i-Crespo, Pau;

(...)

Belloc, Eulalia; Martin, Judit; Millanes-Romero, Alba; Mendez, Raul; Fernandez, Mercedes.

Referència:
GUT 2026.
Posttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation

Belloc, Eulalia; Calderone, Vittorio; Naranjo-Suarez, Salvador; Mateo, Lidia; Martin, Judit;

(...)

Schierwagen, Robert; Trebicka, Jonel; Aloy, Patrick; Fernandez, Mercedes; Mendez, Raul.

Referència:
Science Advances 2026.
CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis

Delgado, ME; Naranjo-Suarez, S; Ramirez-Pedraza, M; Cardenas, BI; Gallardo-Martinez, C;

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Belloc, E; Martin, J; Boyle, M; Mendez, R; Fernandez, M.

Referència:
JHEP Rep 2025.
Cytoplasmic Regulation of the Poly(A) Tail Length as a Potential Therapeutic Target.

Fernandez M; Mendez R;

Referència:
RNA 2025.
Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis

Pell, N; Garcia-Pras, E; Gallego, J; Naranjo-Suarez, S; Balvey, A;

(...)

Schierwagen, R; Rheinwalt, KP; Trebicka, J; Mendez, R; Fernandez, M.

Referència:
Molecular Metabolism 2021.
CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis

Mejias, Marc; Gallego, Javier; Naranjo-Suarez, Salvador; Ramirez, Marta; Pell, Nuria;

Manzano, Anna; Suner, Clara; Bartrons, Ramon; Mendez, Raul; Fernandez, Mercedes.

Referència:
GASTROENTEROLOGY 2020.
Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension

Garcia-Pras, Ester; Gallego, Javier; Coch, Laura; Mejias, Marc; Fernandez-Miranda, Gonzalo;

Pardal, Ricardo; Bosch, Jaime; Mendez, Raul; Fernandez, Mercedes.

Referència:
GUT 2017.
Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress

Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar;

Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul.

Referència:
NATURE CELL BIOLOGY 2017.
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease

Calderone, Vittorio; Gallego, Javier; Fernandez-Miranda, Gonzalo; Garcia-Pras, Ester; Maillo, Carlos;

(...)

Graupera, Mariona; Navarro, Pilar; Bosch, Jaime; Fernandez, Mercedes; Mendez, Raul.

Referència:
GASTROENTEROLOGY 2016.
Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

Mejias, Marc; Coch, Laura; Berzigotti, Annalisa; Garcia-Pras, Ester; Gallego, Javier;

Bosch, Jaime; Fernandez, Mercedes.

Referència:
GUT 2015.