Joan Clària
Grup de recerca
- Inflamació i malaltia hepàtica Group leader (R4)
Publicacions destacades
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Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease
Autors: López-Vicario C, Sebastián D, Casulleras M, Duran-Güell M, Flores-Costa R, Aguilar F, Lozano JJ, Zhang IW, Titos E, Kang JX, Zorzano A, Arita M, Clària J .Referència: Hepatology 2023. -
Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure
Autors: Zhang IW, Curto A, López-Vicario C, Casulleras M, Duran-Güell M, Flores-Costa R, Colsch B, Aguilar F, Aransay AM, Lozano JJ, Hernández-Tejero M, Toapanta D, Fernández J, Arroyo V, Clària J .Referència: Journal Of Hepatology 2022. -
Untargeted lipidomics uncovers lipid signatures distinguishing severe versus moderate forms of acutely decompensated cirrhosis
Autors: Clària J, Curto A, Moreau R, Colsch B, López-Vicario C, Lozano JJ, Aguilar F, Castelli FA, Fenaille F, Junot C, Zhang I, Vinaixa M, Yanes O, Caraceni P, Trebicka J, Fernández J, Angeli P, Jalan R, Arroyo V .Referència: Journal Of Hepatology 2021. -
Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit
Autors: Flores-Costa R, Duran-Güell M, Casulleras M, López-Vicario C, Alcaraz-Quiles J, Diaz A, Lozano JJ, Titos E, Hall K, Sarno R, Masferrer JL, Clària J .Referència: Proceedings Of The National Academy Of Sciences Of The United States Of America 2020. -
Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis
Autors: Casulleras M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E, López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P, Moreau R, Arroyo V, Clària J .Referència: Science Translational Medicine 2020. -
Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis
Autors: López-Vicario C, Checa A, Urdangarin A, Aguilar F, Alcaraz-Quiles J, Caraceni P, Amorós A, Pavesi M, Gómez-Cabrero D, Trebicka J, Oettl K, Moreau R, Planell N, Arroyo V, Wheelock CE, Clària J .Referència: Journal Of Hepatology 2020. -
Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF
Autors: Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ, Junot C, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldassarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin N, Hautbergue T, Cholet S, Castelli F, Jansen C, Steib C, Campion D, Mookerjee R, Rodríguez-Gandía M, Soriano G, Durand F, Benten D, Bañares R, Stauber RE, Gronbaek H, Coenraad MJ, Ginès P, Gerbes A, Jalan R, Bernardi M, Arroyo V, Angeli P, CANONIC Study Investigators of the EASL Clif Consortium, Grifols Chair, European Foundation for the Study of Chronic Liver Failure (EF Clif).Referència: Journal Of Hepatology 2020. -
Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen-Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis
Autors: Alcaraz-Quiles J; Casulleras M; Oettl K; Titos E; Flores-Costa R; Duran-Güell M; López-Vicario C; Pavesi M; Stauber R; Arroyo V; Clària J.Referència: Hepatology 2018. -
Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides
Autors: Lopez-Vicario, Cristina; Alcaraz-Quiles, Jose; Garcia-Alonso, Veronica; Rius, Bibiana; Hwang, Sung H.; Titos, Esther; Lopategi, Aritz; Hammock, Bruce D.; Arroyo, Vicente; Claria, Joan;.Referència: Proceedings Of The National Academy Of Sciences Of The United States Of America 2015. -
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Autors: Spite, Matthew; Claria, Joan; Serhan, Charles N.Referència: Cell Metabolism 2014.
Projectes destacats
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Investigació hepática: recerca bàsica i experimental
Investigador/a principal: Joan Claria EnrichFinançador: Generalitat de CatalunyaCodi: 2021-SGR-01323Durada: 01/01/2022 - 31/12/2024 -
DECISION (Decompensated cirrhosis: identification of new combinatorial therapies based on systems approaches)
Investigador/a principal: Joan Claria EnrichFinançador: European CommissionCodi: CE-H2020-SC1_2019_2sDurada: 01/06/2020 - 31/10/2023 -
MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response
Investigador/a principal: Joan Claria Enrich, Pere Gines GibertFinançador: European CommissionCodi: CE_H2020-SC1_18_1sDurada: 01/01/2019 - 31/03/2025 -
Mecanismos moleculares determinantes de la resolución inadecuada de la inflamación en tejido adiposo obeso. Nuevas oportunidades en la prevención de comorbilidades metabolicas.
Finançador: Ministerio de Economía y CompetitividadCodi: SAF 15/63674-RDurada: 01/01/2016 - 31/12/2019 -
Identification of novel modulators of chronic inflammation in prevalent diseases: unveiling divergent mechanisms of disease
Finançador: Ministerio de Economía y CompetitividadCodi: PIE14/00045Durada: 01/01/2015 - 31/12/2017