Marc Claret
Grup de recerca
- Control neuronal del metabolisme Group leader (R4)
Publicacions destacades
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Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice
Autors: Haddad-Tóvolli R; Altirriba J; Obri A; Sánchez EE; Chivite I; Milà-Guasch M; Ramírez S; Gómez-Valadés AG; Pozo M; Burguet J; Velloso LA; Claret M.Referència: Molecular Metabolism 2020. -
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
Autors: Quiñones M; Al-Massadi O; Folgueira C; Bremser S; Gallego R; Torres-Leal L; Haddad-Tóvolli R; García-Caceres C; Hernandez-Bautista R; Lam BYH; Beiroa D; Sanchez-Rebordelo E; Senra A; Malagon JA; Valerio P; Fondevila MF; Fernø J; Malagon MM; Contreras R; Pfluger P; Brüning JC; Yeo G; Tschöp M; Diéguez C; López M; Claret M; Kloppenburg P; Sabio G; Nogueiras R.Referència: Nature Communications 2018. -
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Autors: Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M .Referència: Cell Metabolism 2017. -
Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
Autors: Schneeberger M, Everard A, Gómez-Valadés AG, Matamoros S, Ramírez S, Delzenne NM, Gomis R, Claret M, Cani PD .Referència: Scientific Reports 2015. -
Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis
Autors: Schneeberger M., Gómez-Valadés A., Altirriba J., Sebastián D., Ramírez S., Garcia A., Esteban Y., Drougard A., Ferrés-Coy A., Bortolozzi A., Garcia-Roves P., Jones J., Manadas B., Zorzano A., Gomis R., Claret M..Referència: Cell Reports 2015. -
Hypothalamic and brainstem neurocircuitries controlling homeostatic energy balance
Autors: Schneeberger, Marc; Gomis, Ramon; Claret, Marc.Referència: Journal Of Endocrinology 2014. -
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance
Autors: Schneeberger, Marc; Dietrich, Marcelo O; Sebastian, David; Imbernon, Monica; Castano, Carlos; Garcia, Ainhoa; Esteban, Yaiza; Gonzalez-Franquesa, Alba; Rodriguez, Ignacio Castrillon; Bortolozzi, Analia; Garcia-Roves, Pablo M; Gomis, Ramon; Nogueiras, Ruben; Horvath, Tamas L; Zorzano, Antonio; Claret, Marc.Referència: Cell 2013. -
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity
Autors: Schneeberger, Marc; Altirriba, Jordi; Garcia, Ainhoa; Esteban, Yaiza; Castano, Carlos; Garcia-Lavandeira, Montserrat; Alvarez, Clara V; Gomis, Ramon; Claret, Marc.Referència: Molecular Metabolism 2013. -
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice
Autors: Claret, Marc; Smith, Mark A; Knauf, Claude; Al-Qassab, Hind; Woods, Angela; Heslegrave, Amanda; Piipari, Kaisa; Emmanuel, Julian J; Colom, Andre; Valet, Philippe; Cani, Patrice D; Begum, Ghazala; White, Anne; Mucket, Phillip; Peters, Marco; Mizuno, Keiko; Batterham, Rachel L; Giese, K Peter; Ashworth, Alan; Burcelin, Remy; Ashford, Michael L; Carling, David; Withers, Dominic J.Referència: Diabetes 2011. -
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.
Autors: Claret M; Smith MA; Batterham RL; Selman C; Choudhury AI; Fryer LG; Clements M; Al-Qassab H; Heffron H; Xu AW; Speakman JR; Barsh GS; Viollet B; Vaulont S; Ashford ML; Carling D; Withers DJ .Referència: Journal Of Clinical Investigation 2007.
Projectes destacats
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Hypothalamic control of gut function and microbiota composition: implications for energy balance regulation (NeuroGut)
Investigador/a principal: Marc Claret CarlesFinançador: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); La CaixaCodi: HR18-00100Durada: 01/11/2019 - 31/10/2022 -
Mitochondrial fusion in endothelial cells: impact on systemic energy and glucose homeostasis
Investigador/a principal: Marc Claret CarlesFinançador: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); European Foundation for the Study of Diabetes (EFSD)Codi: EFSD/NOVO_17_01Durada: 15/02/2018 - 14/02/2020 -
Decoding mitochondrial nutrient-sensing programs in POMC neurons as key determinants of metabolic health (MITOSENSING)
Investigador/a principal: Marc Claret CarlesFinançador: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); European Research Council (ERC) ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (Entidad de origen)Codi: 725004Durada: 01/04/2017 - 31/03/2022 -
Investigating the role of hypothalamic POMC neuron-derived neurosteroids as critical regulators of energy balance and metabolism
Investigador/a principal: Marc Claret CarlesFinançador: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); Instituto de Salud Carlos III (ISCIII)Codi: PI16/00963Durada: 01/01/2017 - 31/12/2019 -
Estudio del papel de la fusión mitocondrial en neuronas hipotalámicas sobre el control del apetito y la regulación del peso corporal: Opa 1 como potencial diana terapéutica para el tratamiento de la obesidad
Investigador/a principal: Marc Claret CarlesFinançador: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); Fundación BBVACodi: BBM-MED-1172Durada: 11/11/2015 - 31/01/2018