Causes of Endometrial cancer

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Any factor that increases the probability of having a disease is called a risk factor. Most cases of endometrial cancer cannot be prevented, but reducing risk factors can lower your chance of developing the disease. However, some women with endometrial cancer have not been exposed to any known risk factors. The most common risk factors for endometrial cancer are: 

Obesity can be cause and/or risk factor of Rheumatoid Arthritis

Obesity: This is a significant risk factor. 

Pill with prescription meds

Oestrogen hormone therapy (without progesterone) after menopause.  

A girl's first menstruation

Early first menstruation (menarche) and/or late menopause, resulting in a increased number of menstrual cycles. 

Woman who cannot get pregnant

Not having been pregnant increase the risk of having this disease. 

Female reproductive system

Polycystic ovary syndrome, anovulatory cycles, infertility. 

A man and a woman over 50 years of age

Old age.

Radiotherapy symbol

Radiation therapy to the pelvis (to treat another cancer). 

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Tamoxifen treatment: This drug is given as adjuvant therapy for breast cancer after surgery and chemotherapy. It has been shown to reduce the probability of recurrence of this tumour. Women who take this drug have a higher risk of developing endometrial cancer, but the risk/benefit ratio advises taking it.

People of different skin tones

Caucasian ethnicity. 

Family tree

Family history of colorectal, endometrial, breast or ovarian cancer. 2-5% of currently diagnosed endometrial cancers are hereditary. The hereditary syndrome most frequently associated with endometrial cancer is Lynch syndrome, which also presents an increased risk of colorectal cancer, gastric cancer and ovarian cancer. In recent years, hereditary breast and ovarian cancer syndrome (BRCA1/2) has been linked to the development of endometrial cancer.  

Substantiated information by:

Ana Carrión Aliaga
Ariel Glickman
Aureli Torné Bladé
Berta Diaz-Feijoo
Lydia Gaba

Published: 9 March 2022
Updated: 9 March 2022

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