Research about ischaemic heart

Research in the field of acute coronary syndrome and myocardial infarction is carried out, mainly via IDIBAPS. Specifically through the Atherosclerosis, coronary disease and heart failure group in the Cardiovascular, renal and respiratory pathobiology and bioengineering area.

The main lines of research are:

• Studying regulatory mechanisms and the effectiveness of stem cell therapy in experimental models and clinical contexts.
• Devising experimental models of neointimal hyperplasia, endothelisation, vascular inflammation and thrombosis.
• Evaluating the influence of hormonal factors, sex and ageing in ischaemic heart disease.
• Designing experimental and clinical studies to assess the behaviour of new devices and strategies to treat coronary artery diseases, including chronic and acute coronary syndromes, cardiogenic shock and cardiac arrest.

The Clínic is also participating in 19 studies or trials in the field of acute coronary syndrome and myocardial infarction:

1. Biomag 2 study (comparing biodegradable magnesium and pharmacoactive cobalt chromium stents)
2. AngioDapt study (Double Antiplatelet Therapy vs. standard therapy in acute and chronic coronary syndrome)
3. Pioneer IV study (functional study of coronary lesions to assess whether they induce ischaemia)
4. Fast III study (comparing two techniques for functional evaluation of coronary injuries)
5. Multivessel Talent study (comparing 2 types of stent in multivessel disease)
6. Stich 3 study (comparing angioplasty with stent and bypass surgery in patient with multivessel disease and left ventricular dysfunction)
7. ProHeal study (comparing the coating of 2 types of stent after angioplasty)
8. Vulnerable study (to evaluate the need to treat injuries which are insignificant but vulnerable after infarction).
9. Combine Intervene study (combines physiology and imaging techniques in the treatment of intermediate lesions)
10. Selution study (comparing stent and pharmacoactive balloon in de novo lesions)
11. Insightful study (comparing microcatheter vs pressure guide for the functional evaluation of coronary lesions)
12. SOS AMI study (to evaluate sealatogrel after a heart attack)
13. Librexia study (to evaluate milvexian after a myocardial infarction)
14. Ischaemia CTO study (evaluating percutaneous revascularisation or optimal medical therapy in the context of chronic coronary occlusion).
15. ExoFIS IP study: Evaluation of therapeutic role and prognosis of the exosomes of mRNA derived from endothelial circulating cells).
16. Project title: “ARTEMIS - Effects of ziltivekimab versus placebo on cardiovascular outcomes in patients with acute myocardial infarction”.   
17. Project title: “A randomized, double-blind, placebo-controlled, multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease (VICTORION-2 PREVENT).” Code: CKJX839B12302. Financing entity: Novartis. Multicenter. Duration: 2022- 2026. PI HCB: Mercè Roqué. Collaborator: Rut Andrea.
18. Project title: “Effect of dapagliflozin in myocardial fibrosis and ventricular function in patients with a ST-segment elevation myocardial infarction: DAPA-STEMI trial”. Financing entity: Spanish Society of Cardiology. Protocol code: ESR-19-14489. EudraCT code: 2018-003105-25. Unicentric. Duration: 2021-2023.  
19. Project title: “Randomized clinical trial assessing the value of Beta-Blockers and Antiplatelet Agents in patients with Spontaneous Coronary Artery Dissection”. Protocol code: BA-SCAD EudraCT Nº: 2021-001905-66 Financing entity: Sociedad Española de Cardiología. Duration: 2021-2023. Multicenter. Global PI: Fernando Alfonso. HCB PI: Manel Sabaté. Co-PI HCB: Rut Andrea.

Professionals dedicated to diagnosis, treatment and research in this disease are involved in different societies, networks and working groups:

• Horizon 2020-RED Europe for the treatment of cardiogenic shock secondary to acute myocardial infarction.
• Technical Committee and Scientific Committee of the Catalonia Infarction Code.
• Extracorporeal Membrane Oxygenation Committee (ECMO) of Catsalut
• Cardiogenic Shock Committee of Catsalut.
• Ischaemic Heart Disease and Acute Cardiac Care Association, as well as the Cardiac Haemodynamics Association in the Spanish Cardiology Society.
• Cardiac Acute Care Working Group of the Catalan Society of Cardiology.
• Clinical Practice Guidelines Committees of the Spanish and European Societies of Cardiology.
• Scientific Committee of the European Society of Cardiology, Spanish Society of Cardiology and the Catalan Society of Cardiology
• Competitive Scholarship Evaluation Committees.
• Spanish Nursing Association in Cardiology.
• Catalan Health Society with a Sex and Gender Perspective
• Coordinator of Sex and Gender in Health Clinical Committees

The Cardiology Unit involves patients with these diseases in several aspects. Participation in the Masters in Cardiovascular Disease Nursing. Participation also in specific educational talks; cardiac rehabilitation programme; post-myocardial infarction cardiac rehabilitation programme; Nordic March cardiovascular protection programme, which coordinates with AISBE professionals.