Resultados de búsqueda

• Characterization of humoral and intrahepatic HBV immune responses and the effect of antiviral therapy

  Although most studies have focused on the analysis of T cell responses in chronic hepatitis B, humoral / B cell responses are important for prevent...

  Investigación – Líneas de investigación

• Strategies of hepatitis C microelimination in our geographical area, focused in PWID and psychiatric populations

  Significant scale-up of treatment among people who inject drugs (PWID) is crucial to achieve WHO hepatitis C virus (HCV) elimination targets. We ha...

  Investigación – Líneas de investigación

• Long-term impact of Hepatitis C cure in patients with advanced liver disease

  Portal hypertension (PH) is the key driver of hepatic decompensation in patients with advanced chronic liver disease. Accordingly, interventions th...

  Investigación – Líneas de investigación

• Understanding the immunopathogenesis of autoimmune hepatitis (AIH) to develop risk stratification tools at presentation

  The incidence of AIH has been steadily increasing within the last decades.  However, standard treatment of the disease, which consists of corticost...

  Investigación – Líneas de investigación

• Evolution of AIH in special populations (pregnancy, compensated and decompensated cirrhosis)

  Approximately 30% of patients with AIH have cirrhosis at the time of diagnosis, and 20-30% of the remaining patients will develop cirrhosis during...

  Investigación – Líneas de investigación

• Identification of biomarkers of success of immunosuppression withdrawal and treatment response in AIH

  We have performed a prospective clinical trial to identify biomarkers able to predict the success of immunosuppression withdrawal in patients with...

  Investigación – Líneas de investigación

• Natural history of modern primary biliary cholangitis (PBC) and predictive factors of portal hypertension in patients in non-cirrhotic patients with PBC

  PBC is chronic liver disease affecting small bile ducts. If left untreated, patients will develop ductopenia and cirrhosis with all its complicatio...

  Investigación – Líneas de investigación

• Impact of exercise programs in the treatment PBC-associated fatigue

  Up to 50% of patients with PBC experience clinically significant fatigue and, it is more common in younger patients. Fatigue diminishes quality of...

  Investigación – Líneas de investigación

• Clinical and biological characterization of patients with Wilson’s disease

  Wilson's Disease is a rare genetic condition characterized by copper deposition mainly in the liver and other tissues afterwards. Clinical presenta...

  Investigación – Líneas de investigación

• Epidemiology of drug-induced liver disease

  The real incidence of drug-induced liver injury is difficult, but it seems clear that it is increasing due to the growth of prescriptions. Epidemio...

  Investigación – Líneas de investigación

• CAR-T cells for the treatment of solid tumours

  After the success of CAR-T cells in hematologic malignancies, the translation of CAR-T cells to solid tumours is the next big challenge in the fiel...

  Investigación – Líneas de investigación

• CAR-T cells for the treatment of hematologic malignancies

  Resistance to CD19-CAR-T cells in hematologic malignancies can appear linked to loss or downregulation of CD19 expression or an immunosuppressive t...

  Investigación – Líneas de investigación

• Understanding the limitations of CAR-T cells in preclinical studies

  The progress of CAR-T cells is limited by a poor understanding of how the design and signaling of these CAR proteins affect T cell efficacy and per...

  Investigación – Líneas de investigación

• Other cancer immunotherapies and combination treatments

  While T-cell based immunotherapies have revolutionized cancer treatment, a majority of patients fail to respond or relapse after a certain period o...

  Investigación – Líneas de investigación

• Development, evaluation and implementation of digital technologies in the field of mental health

  New digital technologies have opened a wide range of opportunities and challenges in the mental health field. During the last decade, our team have...

  Investigación – Líneas de investigación

• Critical conditions for disease onset or prognosis

  To evaluate clinical and molecular features that may condition disease onset, severity, evolution and co-morbidities. Description of the natural hi...

  Investigación – Líneas de investigación

• Identification of genes responsible for genetic disorders

  The strategic objective of this research line is to investigate the genetic, anatomopathological and biochemical bases, as well as the physiopathol...

  Investigación – Líneas de investigación

• Physiopathology of disease

  To search for the physiopatological bases of these diseases we use a combination of the classical and advanced omics technologies (metabolomics, pr...

  Investigación – Líneas de investigación

• Validation of models, mechanisms, and biomarkers of disease

  To confirm the pathogenicity of a certain gene or molecular mechanism, we validate cell models derived from patient to study the disease. We use fi...

  Investigación – Líneas de investigación

• Therapeutic approaches

  This line involves the testing of chemical and peptide libraries, as well as genetic edition strategies. Selection has been made on disease-causing...

  Investigación – Líneas de investigación