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Directed by Sandra Torres We study the progression of MAFLD to hepatocellular carcinoma and drug-induced liver injury (DILI), with special attenti...
The use of physiomimetic experimental models is transforming respiratory research by providing biomimetic environments that closely replicate lung...
Development of a stem cell training program based on individual effects of different biomechanical environmental paràmetres to produce highly thera...
Heavily trained athletes have been found to be at a higher risk of atrial fibrillation and right ventricular arrhythmias than their sedentary count...
The deleterious consequences of high-intensity physical activity may not be limited to the heart. We are currently interested in testing whether he...
We are also interested in uncovering the mechanisms of the deleterious atrial arrhythmogenic cardiac remodelling occurring in the absence of overt...
Directed by Albert Pol Accumulation of lipid droplets is the cellular hallmark of a plethora of prevalent diseases. Understanding the life-cycle...
Directed by Albert Pol We recently described a new antimicrobial function of cytosolic lipid droplets in the cellular defence against intracellul...
Directed by Marta Bosch Lipid droplets are accumulated in multiple inflammatory processes. With especial attention to the pro-inflammatory transc...
Directed by Albert Pol Lipid droplets are a hallmark of multiple cancers, our research focuses in understanding their role in liquid tumours to d...
This project seeks to define the mechanisms underlying the lineage origin and specification of the autoreactive TR1 cells arising in response to pM...
We seek to define the phenotypic, transcriptional and epigenetic make-up of human autoantigen-specific TR1 cells arising in humanized mice in respo...
This project involves the development of novel methodologies to identify candidate pMHC-based nanomedicines for a variety of chronic inflammatory d...
This line of research focuses on studying the role of autophagy in the presentation of type 1 diabetes-relevant autoantigens by thymic and peripher...
This projects seeks to engineer novel recombinant pMHC structures suitable for human therapeutic application.
Directed by Dr. Cristina Fillat Pancreatic carcinogenesis is well defined as a multistage process accompanied by distinct morphological and histo...
Directed by Dr. Cristina Fillat Oncolytic adenoviruses replicate in the tumors leading to oncolysis and triggering an immune cell infiltration in...
Directed by Dr. Cristina Fillat Glutaric aciduria type I (GA-I) is a metabolic inherited disease due to mutations in the GCDH gene. Individuals w...
Obtaining MRI and analysis of the arrhythmia substrate using specialized software.
We aim at comprehensively characterizing the molecular mechanisms responsible for sinusoidal cells de-regulation during the progression of liver pa...