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The loss of neuronal synapses is a phenomenon that occurs in the early stages of neurodegenerative disorders. We hypothesize that synaptic neurodeg...
Ab accumulation is a primary step of Alzheimer’s disease (AD). Noteworthy, while in early-onset familial AD increased Ab burden mainly results from...
Neuroinflammation is a key pathological feature of Alzheimer’s disease (AD) that results primarily from the presence of chronically activated micro...
Directed by Immaculada Baeza The research line has been active for the last fourteen years. Both diseases are considered neurobiological disorder...
Directed by Immaculada Baeza Our group has studied clinical, neuropsychological and brain alterations in adolescents diagnosed with these disorde...
Directed by Luisa Lázaro We study patients’ neuroimaging and genetic characteristics in order to differentiate endophenotypes and also use machin...
Directed by Immaculada Baeza Our group has published studies on cognitive and neuroimaging abnormalities in ASD children and adolescents and thei...
p27 (Kip1), a classical inhibitor of cyclin dependent kinases, is also a transcriptional regulator. We are analysing the mechanisms by which p27 re...
Our research focuses on identifying the molecular mechanism by which the CaMK family regulate cell cycle control and stress response. We are actual...
Multiple myeloma and systemic AL amyloidosis. Minimal residual disease, extramedullary involvement in myeloma, cardiac involvement in amyloidosis,...
Mechanisms of progression and control in patients with multiple myeloma. Molecular and cellular features of patients with long-lasting stable mon...
Natural history and prognosis of chronic myeloid leukemia, myeloproliferative neoplasms, acute myeloid leukemia and myelodysplastic syndromes; prog...
Lymphomas, chronic lymphocytic leukemia and the other lymphoproliferative disorders: Study of progression mechanisms of the disease, genome of CLL...
Based on our clinical and experimental studies on the development of osteoporosis in primary biliary cholangitis, we have confirmed its high preval...
We have analyzed the factors associated with the development of osteoporosis in men and in premenopausal women. These studies are important because...
For years we studied the characteristics of the bone pathology in patients before and after liver transplant. We recently evaluated whether the bon...
We have analyzed the OPG/RANKL system in different conditions: chronic cholestasis and patients with spinal cord injury. We have also analyzed aspe...
For years we have studied the effectiveness of the use of bone turnover markers to analyze the activity of Paget's bone disease. We recently extend...
Co-directed by Dr. Alvar Agusti and Rosa Faner We aim to understand the different respiratory diseases from a life-long perspective (Agusti, Fane...
Directed by Dr. Alvar Agusti The evidence that COPD may originate early in life opens new opportunities for prediction, prevention, personalised...