Resultats de la cerca

• Mechanisms of resistance to targeted therapy

  Treatment with novel targeted drugs like the Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib or the Bcl-2 antagonist venetoclax improved outcome...

  Investigació – Línies d'investigació

• Analyze different biomarkers to predict patients’ outcomes and prognosis

  Patients with different complications of cirrhosis will be prospectively studied. Urine and blood samples will be analyzed to assess the accuracy o...

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• Characterization of systemic and hepatic inflammation and gut microbiome in patients with cirrhosis, encompassing all stages of the disease

  Patients will be divided according to disease stage: from compensated to decompensated and ACLF. Systemic and hepatic inflammation will be investig...

  Investigació – Línies d'investigació

• Screening for liver fibrosis. A population-based study in European countries. The 'LiverScreen' project

  The aim of this project is to prove the cost-effectiveness of screening for liver fibrosis in general population using transient elastography.

  Investigació – Línies d'investigació

• Studying different strategies to halt disease progression

  A multicenter, double-blind, placebo controlled randomized clinical trial to study the safety and efficacy of the combination of simvastatin plus r...

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• Sleep and sleep disorders

  A clinical and electrophysiological assessment of normal sleep in humans and of sleep disorders including the anti-IgLON5 disease, REM sleep behavi...

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• Epilepsy

  Characterization of the epileptogenic activity and the surgical and medical therapy of the refractory epilepsy using functional MRI, video-EEG and...

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• Neuropathic pain

  Electrophysiological evaluation of the neuropathic pain using nocioceptive evoked potentials and other tools including the startle reaction.

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• Motor control

  Assesment of the motor control in healthy subjects and in patients with neurological diseases using acoustic and somatosensorial stimul and prepulse.

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• Precision screening, diagnosis, and staging for enhanced liver cancer outcomes

  Directed by Maria Reig  Effective stratification of patients according to their cancer risk is essential to ensure cost-effective screening progra...

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• Non-invasive prognostic assessment by radiology in liver cancer

  Directed by Jordi Rimola   It is necessary to identify the radiological imaging biomarkers that have the potential to provide valuable prognostic...

  Investigació – Línies d'investigació

• Predictive factors of treatment response in liver cancer

  Directed by Maria Reig  This research line focuses on identifying and understanding key predictive factors that influence the response to surgical...

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• Identification of non-invasive biomarkers of liver injury and new signalling pathways of liver fibroproliferative processes

  Biochemical identification and clinical validation of non-invasive serological markers of liver disease and their complications. Identification of...

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• Evaluation of new strategies to inhibit hepatocyte activity of FoxO1 or to modify the activity of specific Akt targets that have a therapeutic potential to stimulate functional liver regeneration in cirrhotic livers

  Experiments are being carried out in animal models of hepatic regeneration based on partial hepatectomy and toxicity induced by overdose with aceta...

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• Establish new therapies for the normalisation of the intrahepatic vasculature in cirrhotic livers

  These new therapies focus on inhibiting the occurrence of mesenchymal endothelial transition phenomenon, increased endothelial connectivity, inhibi...

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• Evaluation of the therapeutic potential of cerium oxide nanoparticles in experimental models of hepatocellular carcinoma and liver steatosis

  The effects of cerium oxide nanoparticles, antioxidant agents with liver tropism and superoxide dismutase and catalase activity are studied on anim...

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• Evaluation of the utility of collagen matrix implants containing endothelial cells as a cell therapy to stimulate the regenerative layer of cirrhotic livers

  The potential therapeutic effects that healthy endothelial cells immersed in the matrices of collagen can have when interacting and communicating w...

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• Modulation of macrophages to liver damage, regeneration and cancer through functionalised nanoparticles and gene therapy

  Nanoparticles are designed and synthesized to be incorporated by pro-inflammatory macrophages in the cirrhotic liver or by macrophages associated w...

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• Basic and translational research

  Immuno-pathogenesis of HIV infection and mechanisms of HIV control Generation of new immunogens based on defective HIV-based vectors  Developme...

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• Epidemiological research and public health

  Epidemiological studies based on cohorts (PISCIS, ART-CC, COHERE, EuroSida. PROBE-C) STDs in HIV-infected patients. Epidemiology, diagnosis, tre...

  Investigació – Línies d'investigació