Resultats de la cerca

• Integrative epigenomic characterization of normal and neoplastic B cells

  We characterize samples of B cell tumors and normal B cells at different maturation stages through a multi-omics perspective, including DNA methyla...

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• Study the origin and evolution of intraclonal heterogeneity in B cell tumors through single cell technologies

  In collaboration with the single cell genomics group at the CNAG sequencing center in Barcelona, we are studying the transcriptome, epigenome and g...

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• Functional analysis of deregulated transcriptional networks in lymphoid neoplasms

  The analysis of the data generated through the multi-omics profiling strategies is leading to the identification of important regulatory elements a...

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• Decipher the clinical impact of epigenomics in lymphoid neoplasms

  Analyzing our epigenomic data in the context of the clinical behavior of the patients, we apply machine learning methods to identify epigenetic bio...

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• Evolution of the epidemiology of infection in SOT (including HIV-infected patients and donors) and role of the immunosuppressors. Evaluation of the sensitivity and specificity of diagnostic techniques and biological markers and prognostic factors of oppor

  Epidemiological studies of infections collected prospectively in the last 15 years, focusing on their incidence and the evolution of the etiology w...

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• Role of innate and adaptive immunity (including genetic markers) in the risk of infections in SOT

  The study of certain polymorphisms of TLR and MBL in transplanted patients can identify those patients at risk of suffering certain type of infecti...

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• Epidemiological evolution of pulmonary infections in immunosuppressed patients (SOT, HIV, others)

  To develop protocols of action and microbiological diagnostic techniques to be applied to identify pulmonary infections as early as possible in ord...

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• Multicenter research projects within the REIPI. Clinical trials in the area of infections in SOT recipients

  Collaboration and leadership of different studies within the framework of a Spanish research network of infectious diseases and development of prev...

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• Characterisation of neural substrates of vulnerability to psychosis, and relationship with clinical manifestations, in youth in the early stages of psychosis

  We follow-up youth at different stages of risk for psychosis, defined according to genetic and/or clinical criteria, in comparison with healthy vol...

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• Multimodal prediction of psychosis in high risk youth

  We aim to discriminate between groups and predict clinical and functional outcomes based on a combination of clinical, neurocognitive, neuroimaging...

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• Understanding trajectories of change in brain structure / function leading to health and disease during youth

  We are also interested in understanding brain changes associated with cognitive and physical maturation during healthy development, which we have e...

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• New treatment options for youth with emerging psychosis

  We participate in single and multi-center treatment trials testing non-pharmacological (cognitive behavioural therapy for psychosis) and pharmacolo...

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• Syndromes and mechanisms of paraneoplastic and autoimmune encephalitides

  Directed by Josep Dalmau Our research focuses on the discovery and characterization of autoimmune neurological diseases, particularly those mediat...

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• Prognostic factors in early arthritis

  Prognostic factors (clinical and immunogenetic) in patients with recent-onset rheumatoid arthritis. Production of new synthetic citrullinated an...

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• Clinical and sonographic characterization of clinical remission

  Definition and clinical characterization of subclinical 'active synovitis' Immunopathological and molecular characterization of subclinical 'act...

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• Immunopathology of synovitis in chronic arthritis

  Utility in pathogenesis, differential diagnosis and prognosis of rheumatoid arthritis and psoriatic arthritis. Immunopathological changes induced...

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• Pharmacogenomics of chronic arthritis

  Genetic biomarkers associated with biological therapy response in rheumatoid arthritis and psoriatic arthritis

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• The gut-joint axis in rheumatoid arthritis patients: role of microbiota-induced intestinal T follicular helper cells and innate immune cells in the pathogenesis of the disease

  Collaboration with F. Ciccia (Naples University) and G. Schett (Erlangën University) to know the interaction and physiopathological relevance of...

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• Fetal cardiac programming

  Directed by Fàtima Crispi Understanding the effect of pregnancy complications on fetal cardiac development will allow us to discover preventive st...

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• Fetal brain development

  Directed by Elisenda Eixarch We evaluate the prenatal brain development in the most detailed way possible to be able to select the best markers an...

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