Resultats de la cerca

• Artificial intelligence

  Directed by Dr. Ignacio Revuelta We are developing predictive AI models that classify patients in terms of their immunological risk and, consequen...

  Investigació – Línies d'investigació

• Immune response in hepatitis B and D

  Directed by Sabela Lens We investigate the mechanisms of the immune response in chronic HBV and HDV infection to identify determinants of viral co...

  Investigació – Línies d'investigació

• Autoimmune and cholestatic liver diseases

  Directed by Maria Carlota Londoño Research focuses on autoimmune and cholestatic liver diseases, including autoimmune hepatitis, primary biliary c...

  Investigació – Línies d'investigació

• Epidemiology of drug-induced liver injury and Wilson’s disease

  Directed by Xavier Forns We analyze the epidemiology and clinical impact of drug-induced liver injury (DILI), including medications, herbals, and...

  Investigació – Línies d'investigació

• CAR-T cells for the treatment of solid tumours

  After the success of CAR-T cells in hematologic malignancies, the translation of CAR-T cells to solid tumours is the next big challenge in the fiel...

  Investigació – Línies d'investigació

• CAR-T cells for the treatment of hematologic malignancies

  Resistance to CD19-CAR-T cells in hematologic malignancies can appear linked to loss or downregulation of CD19 expression or an immunosuppressive t...

  Investigació – Línies d'investigació

• Understanding the limitations of CAR-T cells in preclinical studies

  The progress of CAR-T cells is limited by a poor understanding of how the design and signaling of these CAR proteins affect T cell efficacy and per...

  Investigació – Línies d'investigació

• Other cancer immunotherapies and combination treatments

  While T-cell based immunotherapies have revolutionized cancer treatment, a majority of patients fail to respond or relapse after a certain period o...

  Investigació – Línies d'investigació

• Development, evaluation and implementation of digital technologies in the field of mental health

  New digital technologies have opened a wide range of opportunities and challenges in the mental health field. During the last decade, our team have...

  Investigació – Línies d'investigació

• Critical conditions for disease onset or prognosis

  To evaluate clinical and molecular features that may condition disease onset, severity, evolution and co-morbidities. Description of the natural hi...

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• Identification of genes responsible for genetic disorders

  The strategic objective of this research line is to investigate the genetic, anatomopathological and biochemical bases, as well as the physiopathol...

  Investigació – Línies d'investigació

• Physiopathology of disease

  To search for the physiopatological bases of these diseases we use a combination of the classical and advanced omics technologies (metabolomics, pr...

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• Validation of models, mechanisms, and biomarkers of disease

  To confirm the pathogenicity of a certain gene or molecular mechanism, we validate cell models derived from patient to study the disease. We use fi...

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• Therapeutic approaches

  This line involves the testing of chemical and peptide libraries, as well as genetic edition strategies. Selection has been made on disease-causing...

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• Ras GTPases: regulation and new roles in tumorigenesis

  Ras proteins are GTPases that regulate signal transduction pathways, which control cell proliferation, differentiation, survival and apoptosis. K-R...

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• Intracellular cholesterol transport and membrane repair in lysosomal diseases

  The endolysosomal (LE/Lys) compartment is the main intracellular reservoir of cholesterol and acts as a sorting center from which cholesterol is de...

  Investigació – Línies d'investigació

• Cell Death, Senescence, and Cancer Precision Medicine

  Led by Dr. J. Montero.  The Montero Lab studies cell death, senescence and cancer precision medicine at the University of Barcelona's Department o...

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• Replication Stress and Autophagy in Chromosome Instability

  Led by C. Mauvezin. Genomic instability is a hallmark of tumor cells, resulting from errors in mitotic progression such as prolonged mitosis, DNA...

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• Translational research in liver cancer

  Our scientific contributions to advancing knowledge in liver cancer during the last 15 years are summarized as follows: we contributed to the class...

  Investigació – Línies d'investigació

• Molecular and immune classification of HCC

  The group contributed to the molecular classification of HCC (Hoshida, NEJM 2008, Chiang Cancer Research 2008) and to the generation of gene signat...

  Investigació – Línies d'investigació