Sobre mi

Cap de grup del Grup 'Predisposició genètica al càncer gastrointestinal' del FRCB-IDIBAPS a Barcelona. Durant més de 30 anys, ha treballat en malalties monogèniques/heredàries humanes i, més recentment, en malalties humanes complexes com el càncer colorectal, el càncer gàstric i el càncer de pàncrees. Va ser coordinador de les Accions COST BM1206 i CA17118 (2013-2022) i reconegut com a Cap de Grup a la seva institució (2015). Les seves activitats de recerca han donat lloc a més de 200 articles en revistes internacionals de gran impacte i ha atret un gran nombre de cites (actualment 8.203), amb un índex H de 48.

Publicacions destacades

  • BMPR2 as a novel predisposition gene for hereditary colorectal polyposis

    Autors: Bonjoch L; Fernandez-Rozadilla C; Alvarez-Barona M; Lopez-Novo A; Herrera-Pariente C; Amigo J; Bujanda L; Remedios D; Dacal A; Cubiella J; Balaguer F; Fernández-Bañares F; Carracedo A; Jover R; Castellvi-Bel S; Ruiz-Ponte C.
    Referència: Gastroenterology 2023.
  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

    Autors: Fernandez-Rozadilla C, Timofeeva M, Chen Z, Law P, Thomas M, Schmit S, Díez-Obrero V, Hsu L, Fernandez-Tajes J, Palles C, Sherwood K, Briggs S, Svinti V, Donnelly K, Farrington S, Blackmur J, Vaughan-Shaw P, Shu XO, Long J, Cai Q, Guo X, Lu Y, Broderick P, Studd J, Huyghe J, Harrison T, Conti D, Dampier C, Devall M, Schumacher F, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Moratalla-Navarro F, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper J, Jenkins M, Win AK, Pai R, Figueiredo J, Haile R, Gallinger S, Woods M, Newcomb P, Duggan D, Cheadle J, Kaplan R, Maughan T, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin LP, Jousilahti P, Knekt P, Aaltonen L, Rissanen H, Pukkala E, Eriksson J, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Zanke B, Männistö S, Albanes D, Weinstein S, Ruiz-Narvaez E, Palmer J, Buchanan D, Platz E, Visvanathan K, Ulrich C, Siegel E, Brezina S, Gsur A, Campbell P, Chang-Claude J, Hoffmeister M, Brenner H, Slattery M, Potter J, Tsilidis K, Schulze M, Gunter M, Murphy N, Castells A, Castellví-Bel S, Moreira L, Arndt V, Shcherbina A, Stern M, Pardamean B, Bishop T, Giles G, Southey M, Idos G, McDonnell K, Abu-Ful Z, Greenson J, Shulman K, Lejbkowicz F, Offit K, Su YR, Steinfelder R, Keku T, van Guelpen B, Hudson T, Hampel H, Pearlman R, Berndt S, Hayes R, Martinez ME, Thomas S, Corley D, Pharoah P, Larsson S, Yen Y, Lenz HJ, White E, Li L, Doheny K, Pugh E, Shelford T, Chan A, Cruz-Correa M, Lindblom A, Hunter D, Joshi A, Schafmayer C, Scacheri P, Kundaje A, Nickerson D, Schoen R, Hampe J, Stadler Z, Vodicka P, Vodickova L, Vymetalkova V, Papadopoulos N, Edlund C, Gauderman W, Thomas D, Shibata D, Toland A, Markowitz S, Kim A, Chanock S, van Duijnhoven F, Feskens E, Sakoda L, Gago-Dominguez M, Wolk A, Naccarati A, Pardini B, FitzGerald L, Lee SC, Ogino S, Bien S, Kooperberg C, Li C, Lin Y, Prentice R, Qu C, Bézieau S, Tangen C, Mardis E, Yamaji T, Sawada N, Iwasaki M, Haiman C, Le Marchand L, Wu A, McNeil C, Coetzee G, Hayward C, Deary I, Harris S, Theodoratou E, Reid S, Walker M, Ooi LY, Moreno V, Casey G, Gruber S, Tomlinson I, Zheng W, Dunlop M, Houlston R, Peters U .
    Referència: Nature Genetics 2023.
  • Germline mutations in WNK2 could be associated with serrated polyposis syndrome

    Autors: Soares de Lima Y, Arnau-Collell C, Muñoz J, Herrera-Pariente C, Moreira L, Ocaña T, Díaz-Gay M, Franch-Expósito S, Cuatrecasas M, Carballal S, Lopez-Novo A, Moreno L, Fernàndez G, Díaz de Bustamante A, Peters S, Sommer AK, Spier I, Te Paske IBAW, van Herwaarden YJ, Castells A, Bujanda L, Capellà G, Steinke-Lange V, Mahmood K, Joo JE, Arnold J, Parry S, Macrae FA, Winship IM, Rosty C, Cubiella J, Rodríguez-Alcalde D, Holinski-Feder E, de Voer R, Buchanan DD, Aretz S, Ruiz-Ponte C, Valle L, Balaguer F, Bonjoch L, Castellvi-Bel S .
    Referència: Journal Of Medical Genetics 2023.
  • Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening

    Autors: Arnau-Collell C; Díez-Villanueva A; Bellosillo B; Augé JM; Muñoz J; Guinó E; Moreira L; Serradesanferm A; Pozo A; Tora-Rocamora I; Bonjoch L; Ibañez-Sanz G; Obon-Santacana M; Moratalla-Navarro F; Sanz-Pamplona R; Márquez CM; Miret RR; Berbegal RP; Velasco GP; Rodríguez CH; Grau J; Castells A; Borras JM; Bessa X; Moreno V; Castellví-Bel S; CRIPREV consortium.
    Referència: Cancer Epidemiology Biomarkers & Prevention 2022.
  • Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility

    Autors: Arnau-Collell C, Soares de Lima Y, Díaz-Gay M, Muñoz J, Carballal S, Bonjoch L, Moreira L, Lozano JJ, Ocaña T, Cuatrecasas M, Díaz de Bustamante A, Castells A, Capellà G, Bujanda L, Cubiella J, Rodríguez-Alcalde D, Balaguer F, Ruiz-Ponte C, Valle L, Moreno V, Castellvi-Bel S .
    Referència: Journal Of Medical Genetics 2020.
  • Germline biallelic MCM8 variants are associated with early-onset Lynch-like syndrome

    Autors: Golubicki M, Bonjoch L, Acuña-Ochoa JG, Díaz-Gay M, Muñoz J, Cuatrecasas M, Ocaña T, Iseas S, Mendez G, Cisterna D, Schubert SA, Nielsen M, van Wezel T, Goldberg Y, Pikarsky E, Robbio J, Roca E, Castells A, Balaguer F, Antelo M, Castellví-Bel S .
    Referència: Jci Insight 2020.
  • Germline Mutations in FAF1 Are Associated With Hereditary Colorectal Cancer

    Autors: Bonjoch L, Franch-Expósito S, Garre P, Belhadj S, Muñoz J, Arnau-Collell C, Díaz-Gay M, Gratacós-Mulleras A, Raimondi G, Esteban-Jurado C, Soares de Lima Y, Herrera-Pariente C, Cuatrecasas M, Ocaña T, Castells A, Fillat C, Capellá G, Balaguer F, Caldés T, Valle L, Castellví-Bel S .
    Referència: Gastroenterology 2020.
  • Using linkage studies combined with whole-exome sequencing to identify novel candidate genes for familial colorectal cancer

    Autors: Toma C, Díaz-Gay M, Franch-Expósito S, Arnau-Collell C, Overs B, Muñoz J, Bonjoch L, Soares de Lima Y, Ocaña T, Cuatrecasas M, Castells A, Bujanda L, Balaguer F, Cubiella J, Caldés T, Fullerton JM, Castellví-Bel S .
    Referència: International Journal Of Cancer 2020.
  • Approaches to functionally validate candidate genetic variants involved in colorectal cancer predisposition.

    Autors: Bonjoch L, Mur P, Arnau-Collell C, Vargas-Parra G, Shamloo B, Franch-Expósito S, Pineda M, Capellà G, Erman B, Castellví-Bel S .
    Referència: Molecular Aspects Of Medicine 2019.
  • Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples

    Autors: Diaz-Gay, Marcos; Vila-Casadesus, Maria; Franch-Exposito, Sebastia; Hernandez-Illan, Eva; Jose Lozano, Juan; Castellvi-Bel, Sergi;.
    Referència: Bmc Bioinformatics 2018.

Projectes destacats

  • Twinning for a European consortium of rectal cancer research institutions through stepping up scientific, technological and innovation excellence of IORS (STEPUPIORS)

    Investigador/a principal: Sergi Castellvi Bel
    Finançador: European Commission
    Codi: HE_WD_21
    Durada: 01/10/2022 - 30/09/2025
  • Colorectal cancer in adolescents and young adults: identification of germline predisposition and somatic insults by a comprehensive multiomic characterization

    Investigador/a principal: Sergi Castellvi Bel
    Finançador: Fundacion Cientifica de la Asociacion Espanola contra el Cancer
    Codi: AECC_Proyectos21
    Durada: 01/12/2021 - 30/11/2024
  • Germline predisposition to serrated polyposis syndrome: functional charaterization of candidate genes by CRISPR-CAS and organoid modeling

    Investigador/a principal: Sergi Castellvi Bel
    Finançador: Fundació La Marató de TV3
    Codi: TV3_Minoritaries_20
    Durada: 30/03/2021 - 29/03/2024
  • Germline predisposition to colorectal cancer: functional characterization of new genes by CRISPR/CAS and organoid modeling (PARAGON)

    Investigador/a principal: Sergi Castellvi Bel
    Finançador: Instituto de Salud Carlos III
    Codi: PI20/00113
    Durada: 01/01/2021 - 31/12/2023
  • Identifying biomarkers through translational research for prevention and stratification of colorectal cancer (TRANSCOLONCAN)

    Investigador/a principal: Sergi Castellvi Bel
    Finançador: European Comission (EU)
    Codi: H2020-CA17118
    Durada: 01/11/2018 - 30/09/2023