Resultats de la cerca

• Analysis of the influence of the microbiota in skin cancer

   Evaluation of the role of the gut microbiome in the modulation of immunotherapy response and melanoma outcome.

  Investigació – Línies d'investigació

• Identification of biomarkers for melanoma

  Study of circulating free DNA (cfDNA) as a biomarker for melanoma surveillance. Study of circulating melanoma cells (CMC) and single cell sequencing.

  Investigació – Línies d'investigació

• Development of new treatment strategies for melanoma and other skin tumors

  Research in the dermatological implications of targeted therapies in melanoma. Immunotherapy in melanoma and non-melanoma skin cancer. Development...

  Investigació – Línies d'investigació

• Study of the mechanisms involved in carcinogenesis and photocarcinogenesis in melanoma and non-melanoma skin cancer

  Analysis of topical and oral photoprotection. Study of UV effect in skin and melanocytic nevi using imaging techniques and high-throughput molecula...

  Investigació – Línies d'investigació

• Functional validation of paternally-derived embryo proteins during early embryogenesis

  The goal of this line emerges from the recent results derived from the integrative analysis of the proteome and transcriptome from human sperm, ooc...

  Investigació – Línies d'investigació

• Characterization of exosomes isolated from seminal fluid and development of clinically relevant diagnostic and prognostic biomarkers

  Exosomes contained in the seminal fluid may contribute proteins and RNAs to the sperm. Our first goal is to characterize the protein and RNA conten...

  Investigació – Línies d'investigació

• Characterization of epigenetic signatures in the sperm chromatin

  We have identified a non-random distribution of proteins and genes along the sperm chromatin domains which may represent epigenetic marks involved...

  Investigació – Línies d'investigació

• Molecular alterations in semen from couples with idiopathic infertility

  Molecular alterations at the transcriptiomic and proteomic level are analyzed in sperm and seminal plasma from couples with idiopathic infertility...

  Investigació – Línies d'investigació

• Genetics of endocrine disorders

  We are  studying the genetic aspects of hereditary endocrine disorders (multiple endocrine neoplasia, congenital adrenal hyperplasia and monogenic...

  Investigació – Línies d'investigació

• Characterization of genes involved in the familial non-syndromic differentiated thyroid carcinoma

  Differentiated familial thyroid carcinoma represents 3-9% of thyroid carcinomas. Today, the genes involved in some rare syndromic forms in which th...

  Investigació – Línies d'investigació

• Mechanisms involved in redifferentiation of cancer cells

  Oncogenesis is essentially a cell dedifferentiation process. Molecules that induce  cell differentiation, such as retinoic acid, have been used for...

  Investigació – Línies d'investigació

• Alcoholism and other addictions, and related comorbidities: new diagnosis tools and treatment

  Examples: 1) Identification of the pattern of cannabis, tobacco, and alcohol use as a function of gender and psychiatric comorbidities that predic...

  Investigació – Línies d'investigació

• Therapeutic use of uric acid as peroxynitrite scavenger in acute ischemic stroke

  Studies at our lab have identified the value of uric acid administration after a brain embolism and how it acts in synergy with reperfusion therapi...

  Investigació – Línies d'investigació

• The chemical optimization of cerebral embolectomy

  Mechanical thrombectomy (MT) increases brain reperfusion and the likelihood of good outcome in patients with acute stroke but only about one third...

  Investigació – Línies d'investigació

• Blood-brain barrier disruption in cerebrovascular diseases

  Blood-brain barrier (BBB) disruption is one of the major deleterious mechanisms implicated in the physiopathology of Central Nervous System disease...

  Investigació – Línies d'investigació

• Brain-gut cross-talk in stroke: targeting gut barrier dysfunction and immune responses to improve stroke outcome

  Infection is a frequent complication of stroke associated with mortality and poor neurological recovery. Recent experimental studies show that post...

  Investigació – Línies d'investigació

• Vascular changes with aging and in animal models of vascular dementia

  Vascular dementia (VaD) is recognized as one of the leading causes of cognitive impairment and dementia in the elderly, and has become one of the m...

  Investigació – Línies d'investigació

• Inflammatory and immune responses to stroke

  Brain cell death after acute stroke triggers inflammation, involving glial and endothelial cell activation, invasion of leukocytes to the damaged t...

  Investigació – Línies d'investigació

• Lipids as intracelular messengers in disease

  Directed by Jose Carlos Fernández-Checa Lipids act as structural molecules, energy sources and signalling factors. Our work has focused on lipid i...

  Investigació – Línies d'investigació

• Lipid cell biology and its impact on metabolic liver disease

  Directed by Carmen Garcia-Ruiz The team research efforts aim to understand the homeostasis and trafficking of cholesterol and sphingolipids in the...

  Investigació – Línies d'investigació