Resultats de la cerca

• Lipids as intracelular messengers in disease

  Directed by Jose Carlos Fernández-Checa Lipids act as structural molecules, energy sources and signalling factors. Our work has focused on lipid i...

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• Lipid cell biology and its impact on metabolic liver disease

  Directed by Carmen Garcia-Ruiz The team research efforts aim to understand the homeostasis and trafficking of cholesterol and sphingolipids in the...

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• Molecular targets of cancer

  Directed by Pilar Navarro Our research focuses on the molecular mechanisms driving tumor progression, with emphasis on pancreatic cancer, tumor-st...

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• Tissue remodeling, fibrosis and cancer

  Directed by Anna Moles Our research investigates tissue remodeling during the onset, progression, and resolution of chronic diseases, with a focus...

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• Inflammasome activation and mitochondrial stress in the progression of MAFLD to hepatocellular carcinoma and DILI

  Directed by Sandra Torres We study the progression of MAFLD to hepatocellular carcinoma and drug-induced liver injury (DILI), with special attenti...

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• Development of physiomimetic experimental models

  The use of physiomimetic experimental models is transforming respiratory research by providing biomimetic environments that closely replicate lung...

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• Optimization of stem cell therapy for acute lung injury

  Development of a stem cell training program based on individual effects of different biomechanical environmental paràmetres to produce highly thera...

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• Mechanisms of cardiac arrhythmias in high-level athletes

  Heavily trained athletes have been found to be at a higher risk of atrial fibrillation and right ventricular arrhythmias than their sedentary count...

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• Extra-cardiac consequences of very high-intensity physical activity

  The deleterious consequences of high-intensity physical activity may not be limited to the heart. We are currently interested in testing whether he...

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• Characterization of the pathophysiology of cardiac arrhythmias

  We are also interested in uncovering the mechanisms of the deleterious atrial arrhythmogenic cardiac remodelling occurring in the absence of overt...

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• Understanding the biogenesis and consumption of lipid droplets: decoding the metabolic syndrome?

  Directed by Albert Pol  Accumulation of lipid droplets is the cellular hallmark of a plethora of prevalent diseases. Understanding the life-cycle...

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• Lipid droplets as innate immunity hubs

  Directed by Albert Pol  We recently described a new antimicrobial function of cytosolic lipid droplets in the cellular defence against intracellul...

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• Lipid droplets role in inflammation

  Directed by Marta Bosch  Lipid droplets are accumulated in multiple inflammatory processes. With especial attention to the pro-inflammatory transc...

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• Lipid droplets, a new cancer hallmark

  Directed by Albert Pol  Lipid droplets are a hallmark of multiple cancers, our research focuses in understanding their role in liquid tumours to d...

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• Lineage-specification of pMHC-NP-induced antigen-specific T-regulatory type 1 (TR1) cells

  This project seeks to define the mechanisms underlying the lineage origin and specification of the autoreactive TR1 cells arising in response to pM...

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• Phenotypic, transcriptional and epigenetic make up of pMHC-NP-induced human autoantigen-specific TR1 cells in humanized mouse models

  We seek to define the phenotypic, transcriptional and epigenetic make-up of human autoantigen-specific TR1 cells arising in humanized mice in respo...

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• Advancing antigen-specific nanomedicines for the treatment of organ-specific and systemic autoimmune diseases

  This project involves the development of novel methodologies to identify candidate pMHC-based nanomedicines for a variety of chronic inflammatory d...

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• Role of autophagy in autoantigen presentation during T-cell ontogeny and autoimmunity

  This line of research focuses on studying the role of autophagy in the presentation of type 1 diabetes-relevant autoantigens by thymic and peripher...

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• Engineering of recombinant peptide-major histocompatibility complexes suitable for eliciting autoreactive T-regulatory type 1 cells in vivo

  This projects seeks to engineer novel recombinant pMHC structures suitable for human therapeutic application.

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• Understanding pancreatic carcinogenesis

  Directed by Dr. Cristina Fillat  Pancreatic carcinogenesis is well defined as a multistage process accompanied by distinct morphological and histo...

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