Resultats de la cerca

• Identification of genetic biomarkers and drug targets

  Our final goal is to identify target genes/pathways that can be useful biomarkers in the management of pediatric NHL. In detail, we aim to identify...

  Investigació – Línies d'investigació

• 1. Ischemia-reperfusion injury and expanding criteria for liver graft acceptance

  Maintaining the viability of organs from their recovery to transplantation is a key factor for transplant success and graft survival. Organ damage...

  Investigació – Línies d'investigació

• 2. Endoscopic management of biliary complications following liver transplantation

  The study of biliary complications after liver transplantation has high clinical relevance, due it relatively high incidence, complexity of managem...

  Investigació – Línies d'investigació

• 3. Expanding indications for liver transplantation in relation to pre-existing portal vein thrombosis and portal hypertension

  It is widely known that portal vein thrombosis is a serious complication of chronic liver disease, and the prognosis of liver transplantation depen...

  Investigació – Línies d'investigació

• 4. Expanding indications for transplantation for malignant tumors – hilar cholangiocarcinoma and colorectal cancer liver metastases

  The decrease in the number of patients on liver transplant waiting lists due to the advent of effective treatment for hepatitis C virus has generat...

  Investigació – Línies d'investigació

• 5. Alloimmune response, complications associated with immunosupression, and operational tolerance

  Treatment with immunosupression is associated with a series of risks for the transplanted patient, making minimization key to optimizing post-trans...

  Investigació – Línies d'investigació

• 6. Prevention and treatment of cardiovascular risk factors following liver transplantation

  Cardiovascular diseases represent one of the most common causes of long-term morbidity and mortality after liver transplantation. This group focuse...

  Investigació – Línies d'investigació

• Clinical applicability of genomic copy-number alterations and aneuploidy

  Chromosomal aneuploidy results in the acquisition of copy-number alterations, which occur early in tumorigenesis and are positively selected throug...

  Investigació – Línies d'investigació

• Intratumor heterogeneity as a novel biomarker in colorectal cancer

  Elucidating the role of genomic instability, which represents the molecular engine that fuels intratumor heterogeneity in carcinomas, is critical f...

  Investigació – Línies d'investigació

• Functional consequences of whole-genome doubling and its impact on disease outcome

  There is growing evidence that whole-genome doubling occurs early in tumorigenesis and triggers genetically unstable near-tetraploid cells. In addi...

  Investigació – Línies d'investigació

• 1-Which is the role of translational control of gene expression in liver disease and cancer?

  To understand the molecular mechanisms involved in the development and progression of liver disease and cancer, with a focus on the aberrant reprog...

  Investigació – Línies d'investigació

• 2-What is the significance and underlying mechanisms linking obesity with liver disease and cancer?

  To decipher mechanisms underpinning the detrimental impact of obesity in liver disease and cancer. This knowledge is crucial for advancements in tr...

  Investigació – Línies d'investigació

• 3-How does deregulation of pathways that control angiogenesis contribute to progression of liver disease and cancer?

  To define the molecular and cellular mechanisms that regulate/dysregulate angiogenesis in liver disease and cancer and define their functional rele...

  Investigació – Línies d'investigació

• 2-Multiple sclerosis and other demyelinating syndromes

  This work is leading to a comprehensive understanding of the etiology and pathophysiology of demyelinating disorders including multiple sclerosis,...

  Investigació – Línies d'investigació

• 3-Pediatric neuroimmunologic diseases

  This research is focused on identifying new antigens associated with pediatric autoimmune encephalitis and demyelinating diseases, characterizing t...

  Investigació – Línies d'investigació

• Advanced Therapies

  Coordination of the transfer of basic research in advanced therapies from the Hospital Clínic to its clinical application, through the scientific e...

  Investigació – Línies d'investigació

• Pharmacovigilance

  Research on the molecular and pathophysiological mechanisms of adverse drug reactions and implementation of active pharmacovigilance systems that a...

  Investigació – Línies d'investigació

• Support to clinical research: Design, methodology, regulatory, project management, monitoring, data management and statistics

  Optimization of methodological and statistical support for clinical research and full-service CRO for phase I-IV clinical trials sponsored by acade...

  Investigació – Línies d'investigació

• Ethics in clinical research

  Search for quality and the extent and context of application of current ethical principles in clinical research projects. It is developed in group...

  Investigació – Línies d'investigació

• Pharmacogenetics and pharmacogenomics

  Development of studies to relate genetics with the activity and response to the action of drugs.

  Investigació – Línies d'investigació