Resultats de la cerca

• Extramedullary involvement in multiple myeloma

  The extramedullary involvement in multiple myeloma is associated with a poor response to therapy and to a shortened survival. Our group is largely...

  Investigació – Línies d'investigació

• Cardiac involvement in AL amyloidosis

  The degree of cardiac involvement is the critical prognostic marker in AL amyloidosis. Our institution is a reference center for this disease and o...

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• Clinical trials

  We are developing a number of clinical trials with new drugs and new drug combinations in multiple myeloma and also in AL amyloidosis. Of note, Dr....

  Investigació – Línies d'investigació

• 1. Epidemiology, prevention and new treatments of pneumonias associated with artificial ventilation and new methods of fast diagnosis

  Risk factors, Resistances of microorganisms. Local and systemic inflammatory response. New therapies.

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• 2. Epidemiology and diagnosis of community-acquired pneumonia

  Multicenter studies in the setting of community-acquired pneumonia. New methods for fast diagnosis. New treatments. Resistances of microorganisms....

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• 3. Etiopathogenesis, bronchial infection and inflammation in the patient with chronic obstructive pulmonary disease (COPD

  Role of infections in exacerbation of the disease. Study of bronchial and associated systemic response. Analysis of the risk and prognostic factors...

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• 4. Chronic pulmonary infections

  Bronchiectasis not associated with cystic fibrosis, immune deficiencies and cystic fibrosis in the adult. Control of bronchial colonization. Study...

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• 5. Infectious lung complications in immune depressed patients

  Evaluation of the etiological factors. Optimization of the diagnostic techniques. Study of bronchial inflammatory and associated systemic response....

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• 6. Invasive and noninvasive mechanical ventilation

  Epidemiology, costeffectiveness and physiopathology. New techniques. Weaning from mechanical ventilation: role of the inflammatory response and res...

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• 7. Porcine model of acute pulmonary damage due to methicillinresistant P. aeruginosa, S. aureus and S. pneumoniae

  Study of new coadjuvant drugs, antibiotics and therapies for pneumonia, prevention of ventilator-associated pneumonia (VAP), and new forms of mecha...

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• 8. Translational research laboratory for the microbiology diagnosis and pathogen-host response in respiratory infections

  Respiratory microbiome, advanced and rapid microbiology diagnostic, biofilm associated acute and chronic respiratory infections, advanced imaging i...

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• 9. Chronic sleep apnea

  Chronic sleep apnea models Multicenter Study to assess the effect of CPAP on cardiovascular diseases in patients with sleep apnea Telematic c...

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• Systemic lupus erythematosus, antiphospholipid syndrome and systemic sclerosis

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Clinical trials in new biological t...

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• Sjögren’s syndrome, autoimmune manifestations of hepatitis C virus infection and biological therapies

  Epidemiological multicenter studies on the clinical manifestations and long-term evolution of these diseases Study of IgG4 disease associated wi...

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• 1. CAR-T and CAR-NK therapy for the treatment of hematological malignancies

  Directed by Álvaro Urbano Preclinical development of CARs for the treatment of malignant diseases. Specifically, we have developed a CAR against B...

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• The dynamics of evidence integration during decision making

  Directed by Jaime de la Rocha We study how information, acquired from sensation or from previous experiences, is transformed into decision variabl...

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• The neural circuitry of Working Memory (WM): memory interference and disease-mediated deficits

  Directed by Jaime de la Rocha We study how the brain maintains and uses information over short periods (working memory) using behavioral tasks in...

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• Midbrain circuitry mediating instrumental learning

  Directed by Hernando Martinez Vergara The Basal Ganglia (BG) are critical for learning, allowing vertebrates to adapt their behavior to maximize u...

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• 2. CAR-T cell therapies for solid tumours

  Directed by Álvaro Urbano We are developing novel CAR-T cell therapies for the treatment of solid tumours, with a primary focus on breast and ovar...

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• 3. Mechanisms of antitumor cytotoxicity of immune cells (NK and T lymphocytes)

  Directed by Álvaro Urbano We use both NK cells and CAR-NK cells to increase the activity of CART cells avoiding CART cell exhaustion and increasin...

  Investigació – Línies d'investigació