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Although most studies have focused on the analysis of T cell responses in chronic hepatitis B, humoral / B cell responses are important for prevent...
Significant scale-up of treatment among people who inject drugs (PWID) is crucial to achieve WHO hepatitis C virus (HCV) elimination targets. We ha...
Portal hypertension (PH) is the key driver of hepatic decompensation in patients with advanced chronic liver disease. Accordingly, interventions th...
The incidence of AIH has been steadily increasing within the last decades. However, standard treatment of the disease, which consists of corticost...
Approximately 30% of patients with AIH have cirrhosis at the time of diagnosis, and 20-30% of the remaining patients will develop cirrhosis during...
We have performed a prospective clinical trial to identify biomarkers able to predict the success of immunosuppression withdrawal in patients with...
PBC is chronic liver disease affecting small bile ducts. If left untreated, patients will develop ductopenia and cirrhosis with all its complicatio...
Up to 50% of patients with PBC experience clinically significant fatigue and, it is more common in younger patients. Fatigue diminishes quality of...
Wilson's Disease is a rare genetic condition characterized by copper deposition mainly in the liver and other tissues afterwards. Clinical presenta...
The real incidence of drug-induced liver injury is difficult, but it seems clear that it is increasing due to the growth of prescriptions. Epidemio...
After the success of CAR-T cells in hematologic malignancies, the translation of CAR-T cells to solid tumours is the next big challenge in the fiel...
Resistance to CD19-CAR-T cells in hematologic malignancies can appear linked to loss or downregulation of CD19 expression or an immunosuppressive t...
The progress of CAR-T cells is limited by a poor understanding of how the design and signaling of these CAR proteins affect T cell efficacy and per...
While T-cell based immunotherapies have revolutionized cancer treatment, a majority of patients fail to respond or relapse after a certain period o...
New digital technologies have opened a wide range of opportunities and challenges in the mental health field. During the last decade, our team have...
To evaluate clinical and molecular features that may condition disease onset, severity, evolution and co-morbidities. Description of the natural hi...
The strategic objective of this research line is to investigate the genetic, anatomopathological and biochemical bases, as well as the physiopathol...
To search for the physiopatological bases of these diseases we use a combination of the classical and advanced omics technologies (metabolomics, pr...
To confirm the pathogenicity of a certain gene or molecular mechanism, we validate cell models derived from patient to study the disease. We use fi...
This line involves the testing of chemical and peptide libraries, as well as genetic edition strategies. Selection has been made on disease-causing...