Resultats de la cerca

• Ras GTPases: regulation and new roles in tumorigenesis

  Ras proteins are GTPases that regulate signal transduction pathways, which control cell proliferation, differentiation, survival and apoptosis. K-R...

  Investigació – Línies d'investigació

• Intracellular cholesterol transport and membrane repair in lysosomal diseases

  The endolysosomal (LE/Lys) compartment is the main intracellular reservoir of cholesterol and acts as a sorting center from which cholesterol is de...

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• Cell Death, Senescence, and Cancer Precision Medicine

  Led by Dr. J. Montero.  The Montero Lab studies cell death, senescence and cancer precision medicine at the University of Barcelona's Department o...

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• Replication Stress and Autophagy in Chromosome Instability

  Led by C. Mauvezin. Genomic instability is a hallmark of tumor cells, resulting from errors in mitotic progression such as prolonged mitosis, DNA...

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• Translational research in liver cancer

  Our scientific contributions to advancing knowledge in liver cancer during the last 15 years are summarized as follows: we contributed to the class...

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• Molecular and immune classification of HCC

  The group contributed to the molecular classification of HCC (Hoshida, NEJM 2008, Chiang Cancer Research 2008) and to the generation of gene signat...

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• Identification of determinants of response to immunotherapy in HCC

  We developed an 11-gene signature able to predict response to immune checkpoint inhibitors in HCC (Haber Gastroenterology 2022). We also contribute...

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• Molecular characterization of human NASH-HCC

  We have molecularly characterized human NASH-HCC at the genomic and molecular levels (Pinyol Journal of Hepatology 2021). 

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• Identification of drivers of oncogenesis as targets for therapies in HCC

  Several studies led to the identification of Akt/mTOR pathway [Villanueva Gastroenterology, 2008), EGFR pathway (Keng, Nature Biotech 2009), IGF pa...

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• Establishment of a molecular diagnosis and classification of HCC

  Gene-set (three genes) based diagnosis of HCC reported in Llovet, Gastroenterology 2006, and included in EASL-EORTC guidelines. In addition, we pro...

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• Molecular characterization and identification of drivers of oncogenesis in cholangiocarcinoma

  We have contributed to the molecular classification of iCCA (Sia, Gastroenterology 2013) and eCCA (Montal, Journal of Hepatology 2020).  We identi...

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• Establishment of sorafenib, regorafenib and ramucirumab as standard of care in patients with advanced HCC

  The international RCT showing survival benefits for sorafenib vs placebo, presented at plenary session in ASCO (Llovet, New Engl J Med 2008) was a...

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• Cannabis use disorders and risky cannabis use

  Examples: 1) Influence of introducing the construct of "cannabis risk use" with a co-created formative intervention on cannabis health literacy in...

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• Addictions prevention, addictions workforce & training, and public health

  Examples: 1) Workforce in Addictions - Valorisation in Europe (WAVE) 2) https://interglam.eu/ 3) https://www.deep-seas.eu/ 4) https://far-seas....

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• Digital health and Addictions

  Example: IBM-ABJ: Motivational Brief Intervention combined with Game-Based Learning to improve retention in treatment of patients with alcohol-rela...

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• Genomic alterations in aggressive large B-cell lymphoma

  Directed by Silvia Beà To comprehensively characterize the genetic and molecular profiles of aggressive B-cell lymphomas in order to identify accu...

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• Head Neck Tumors

  Directed by Dr. Isabel Vilaseca, Dr. F. Xavier Avilés and Dr. Neus Basté Multiomic characterisation of head and neck cancer and its impact in a...

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• CAF Plasticity and Heterogeneity in desmoplastic tumors

  We are interested in deciphering and dissecting the plasticity and heterogeneity of cancer-associated fibroblasrs (CAF) during cholangiocarcinogene...

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• Cancer Stem Cells in intrahepatic cholangiocarcinoma

  Combining in vitro and in vivo systems with high throughput transcriptomics and bioinformatics, we aim to elucidate the functional role of cancer s...

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• Tracing Intra-Tumoral Heterogenenity

  Tumors are highly heterogeneous entities, and we are interested in investigating the interactions between heterogeneous cancer cells and the tumor...

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