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• Non invasive characterization of arrhythmia substrate

  We aim to characterize the myocardial and electrical substrate in patients with atrial fibrillation and ventricular tachycardia in order to improve...

  Investigación – Líneas de investigación

• Characterization of cardiac mechanics in heart failure

  We aim to quantify and precisely describe underlying abnormalities in cardiac mechanics that could be corrected to improve the outcomes of patients...

  Investigación – Líneas de investigación

• Prediction of atrial fibrillation in patients at risk (Predict AF study)

  We aim to establish non invasive risk biomarkers based on imaging and blood tests to identify subjects that will develop atrial fibrillation in ord...

  Investigación – Líneas de investigación

• Identification of patients at risk of sudden death and heart failure after myocardial infarction

  We aim to characterize myocardial scar and cardiac remodelling to improve our identification of patients who will develop malignat ventricular arrh...

  Investigación – Líneas de investigación

• Identification of athletes at risk of sudden death

  We aim to characterize cardiac remodelling in response to exercise training and to identify those atletes at risk of presenting sudden death. Also,...

  Investigación – Líneas de investigación

• Characterization of hypertrophic hearts (INDEPTH-HCM)

  We aim to perform a in-depth myocardial characterization of hypertrophic cardiomyopathy: comprehensive multimodality imaging, tissue characterizati...

  Investigación – Líneas de investigación

• Identification of candidates for and impact of percutaneous therapies for heart valve disease

  We aim to understand the changes in valvular geometry and cardiac performance before and after implantation of novel percutanoeusly implanted devic...

  Investigación – Líneas de investigación

• Usefulness of non-invasive cardíac imaging in the identification of acute coronary syndromes

  We explore the additive diagnostic value of several non-invasive cardiac imaging modalities for the identification of acute coronary syndrome among...

  Investigación – Líneas de investigación

• To investigate the role of mitochondrial DNA in synapse elimination and neurodegeneration in genetic models of neurodegenerative diseases

  The loss of neuronal synapses is a phenomenon that occurs in the early stages of neurodegenerative disorders. We hypothesize that synaptic neurodeg...

  Investigación – Líneas de investigación

• To study the mechanisms that alter amyloid beta (Aβ) clearance and disposal of dysfunctional mitochondria

  Ab accumulation is a primary step of Alzheimer’s disease (AD). Noteworthy, while in early-onset familial AD increased Ab burden mainly results from...

  Investigación – Líneas de investigación

• Study the role of mitochondrial function in neuroinflammation and amyloid beta (Aβ)-induced cell death

  Neuroinflammation is a key pathological feature of Alzheimer’s disease (AD) that results primarily from the presence of chronically activated micro...

  Investigación – Líneas de investigación

• Psychotic and affective disorders in children and adolescents

  The research line has been active for the last fourteen years. Both diseases are considered neurobiological disorders with an important genetic com...

  Investigación – Líneas de investigación

• Anorexia and other eating disorders

  Our group has studied clinical, neuropsychological and brain alterations in adolescents diagnosed with these disorders over the last fifteen years....

  Investigación – Líneas de investigación

• Obsessive-compulsive disorder (OCD) and Tourette syndrome

  We study patients’ neuroimaging and genetic characteristics in order to differentiate endophenotypes and also use machine learning methodology to p...

  Investigación – Líneas de investigación

• Autism spectrum disorders (ASD)

  Our group has published studies on cognitive and neuroimaging abnormalities in ASD children and adolescents and their siblings as well as ongenetic...

  Investigación – Líneas de investigación

• Involvement of p27 (Kip1) in cancer progression

  p27 (Kip1), a classical inhibitor of cyclin dependent kinases, is also a transcriptional regulator. We are analysing the mechanisms by which p27 re...

  Investigación – Líneas de investigación

• Protein kinases in cancer

  Our research focuses on identifying the molecular mechanism by which the CaMK family regulate cell cycle control and stress response. We are actual...

  Investigación – Líneas de investigación

• Myeloma and other monoclonal gammapathies

  Multiple myeloma and systemic AL amyloidosis. Minimal residual disease, extramedullary involvement in myeloma, cardiac involvement in amyloidosis,...

  Investigación – Líneas de investigación

• Mechanisms of progression in monoclonal gammopathies

  Mechanisms of  progression and control in patients with multiple myeloma. Molecular and cellular features of  patients with long-lasting stable mon...

  Investigación – Líneas de investigación

• Myeloid neoplasmas

  Natural history and prognosis of chronic myeloid leukemia, myeloproliferative neoplasms, acute myeloid leukemia and myelodysplastic syndromes; prog...

  Investigación – Líneas de investigación