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• Precision screening, diagnosis, and staging for enhanced liver cancer outcomes

  Directed by Maria Reig  Effective stratification of patients according to their cancer risk is essential to ensure cost-effective screening progra...

  Investigación – Líneas de investigación

• Non-invasive prognostic assessment by radiology in liver cancer

  Directed by Jordi Rimola   It is necessary to identify the radiological imaging biomarkers that have the potential to provide valuable prognostic...

  Investigación – Líneas de investigación

• Predictive factors of treatment response in liver cancer

  Directed by Maria Reig  This research line focuses on identifying and understanding key predictive factors that influence the response to surgical...

  Investigación – Líneas de investigación

• Identification of non-invasive biomarkers of liver injury and new signalling pathways of liver fibroproliferative processes

  Biochemical identification and clinical validation of non-invasive serological markers of liver disease and their complications. Identification of...

  Investigación – Líneas de investigación

• Evaluation of new strategies to inhibit hepatocyte activity of FoxO1 or to modify the activity of specific Akt targets that have a therapeutic potential to stimulate functional liver regeneration in cirrhotic livers

  Experiments are being carried out in animal models of hepatic regeneration based on partial hepatectomy and toxicity induced by overdose with aceta...

  Investigación – Líneas de investigación

• Establish new therapies for the normalisation of the intrahepatic vasculature in cirrhotic livers

  These new therapies focus on inhibiting the occurrence of mesenchymal endothelial transition phenomenon, increased endothelial connectivity, inhibi...

  Investigación – Líneas de investigación

• Evaluation of the therapeutic potential of cerium oxide nanoparticles in experimental models of hepatocellular carcinoma and liver steatosis

  The effects of cerium oxide nanoparticles, antioxidant agents with liver tropism and superoxide dismutase and catalase activity are studied on anim...

  Investigación – Líneas de investigación

• Evaluation of the utility of collagen matrix implants containing endothelial cells as a cell therapy to stimulate the regenerative layer of cirrhotic livers

  The potential therapeutic effects that healthy endothelial cells immersed in the matrices of collagen can have when interacting and communicating w...

  Investigación – Líneas de investigación

• Modulation of macrophages to liver damage, regeneration and cancer through functionalised nanoparticles and gene therapy

  Nanoparticles are designed and synthesized to be incorporated by pro-inflammatory macrophages in the cirrhotic liver or by macrophages associated w...

  Investigación – Líneas de investigación

• Basic and translational research

  Immuno-pathogenesis of HIV infection and mechanisms of HIV control Generation of new immunogens based on defective HIV-based vectors  Developme...

  Investigación – Líneas de investigación

• Epidemiological research and public health

  Epidemiological studies based on cohorts (PISCIS, ART-CC, COHERE, EuroSida. PROBE-C) STDs in HIV-infected patients. Epidemiology, diagnosis, tre...

  Investigación – Líneas de investigación

• Systemic vasculitis. Mechanisms involved in inflammation and vascular remodeling as a source of biomarkers of clinical utility and therapeutic innovation

  Accurate characterization of patient cohorts (systemic vasculitis) according to relevant outcomes (diease extent, relapsing disease, complication...

  Investigación – Líneas de investigación

• Proliferation and apoptosis in pulmonary arterial hypertension: biomarkers and new therapies

  PH is a severe condition causing significant burden. Fortunately, recent advances in the understanding of the pathobiology of PH have prompted the...

  Investigación – Líneas de investigación

• Interventions on lifestyle: exercise and other non-pharmacological actions to improve PH

  Targeting lifestyle in PH may improve the disease. To demonstrate it, an experimental model of PH, assessing the effects of exercise training on pl...

  Investigación – Líneas de investigación

• Clinical research in pulmonary hypertension

  We have two core facilities available –patient registries and biological repositories–, which are already implemented and will contribute to facili...

  Investigación – Líneas de investigación

• Functional aspects of the hospital Emergency departments

  This line of research studies the incorporation of the LEAN methodology or “LEAN thinking” in the Emergency department. The use of tools and method...

  Investigación – Líneas de investigación

• Acute heart failure

  This line has the aim of providing scientific evidence in patients with acute heart faliure (AHF) who consult in the emergency department. In one h...

  Investigación – Líneas de investigación

• Evaluation of chest pain in the emergency department

  Chest pain is one of the most freqüent complains in the emergency department, with etiologies that can range from banal to life-threatening patholo...

  Investigación – Líneas de investigación

• Clinical aspects of intoxicated patients and medical care for problems caused by drug abuse

  This research is focused on the study of patients intoxicated by both medicines and abuse drugs whose consumption is increasing progressively in re...

  Investigación – Líneas de investigación

• Attention to infectious diseases in emergency departments

  Infectious diseases are very prevalent in the Emergency department, often associated a difficulties in the diagnostic. The developement of biomarke...

  Investigación – Líneas de investigación