Resultats de la cerca

• 1. CAR-T and CAR-NK therapy for the treatment of hematological malignancies

  Preclinical development of CARs for the treatment of malignant diseases. Specifically, we have developed a CAR against BCMA, which can be used for...

  Investigació – Línies d'investigació

• The neural circuitry of expectation during decision making tasks

  In this project, funded by the European Research Council (ERC-2015-CoG - 683209_PRIORS), we aim to characterize the neural basis of expectation, an...

  Investigació – Línies d'investigació

• The dynamics of sensory evidence integration during perceptual decision making

  During perceptual discrimination task sensory information must be transformed into decision evidence and then temporally integrated in order to yie...

  Investigació – Línies d'investigació

• The neural circuitry of Working Memory (WM): memory interference and disease-mediated deficits

  Working memory is the cognitive function describing the maintenance and processing of information in the brain during brief periods of time. The br...

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• 2. CAR-T cell therapies for solid tumours

  We are developing novel CAR-T cell therapies for the treatment of solid tumours, with a primary focus on breast and ovarian cancers. Studies are un...

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• 3. Mechanisms of antitumor cytotoxicity of immune cells (NK and T lymphocytes)

  We use both NK cells and CAR-NK cells to increase the activity of CART cells avoiding CART cell exhaustion and increasing the antileukemic activity...

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• 4. Allogeneic stem cell transplantation: graft versus host disease (GVHD) and Infectious complications

  GVHD and Infectious complications are the main problems occurring after allogeneic stem cell transplantation, being responsible for a mortality rat...

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• Study of the molecular mechanisms involved in the development of bleeding and thrombotic disorders

  Our group’s scientific trajectory is focused on the study of the mechanisms involved in the development of haemorrhagic pathologies, particularly t...

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• Characterization of endothelial dysfunction in association with different pathological situations

  Some diseases have a high cardiovascular risk, such as chronic kidney failure, diabetes, and obesity, among others, in which we surmise that endoth...

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• Search for biomarkers of graft-versus-host disease (GvHD)

  We have identified certain endothelial damage in the context of transplanted haematopoietic progenitor cells in patients. The behaviour of these ma...

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• Diagnosis and treatment of thrombotic microangiopathies

  Thrombotic microangiopathies (TMAs) have matching symptoms but may be due to quite different causes. Differential diagnosis of thrombotic thrombocy...

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• Evaluation of the physiological and pathological implications of circulating and/or platelet associated procoagulant microparticles in atherothrombosis

  Platelet-derived microparticles facilitate interaction with other cell groups and may have a prothrombotic effect in certain pathological situation...

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• Clinical cohorts of prodromal & established disease

  We have built unique prospective cohorts for the clinical and biological characterization of at-risk and prodromal Parkinson’s disease cohorts, e.g...

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• Novel diagnostic & prognostic biomarkers

  We seek, set-up and introduce clinically meaningful biomarkers. Hence, we pioneered the alpha-synuclein seed amplification assay in CSF, being the...

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• Innovative tissue & cellular models of disease

  We investigate the pathophysiological mechanisms and pathways to unravel novel therapeutic targets of neurodegenerative movement disorders using hu...

  Investigació – Línies d'investigació

• 1. Deep phenotyping of pulmonary hypertension in chronic respiratory diseases

  Our group is currently investigating the endogenous phenotype that determines the heterogeneity of pulmonary hypertension in chronic airway obstruc...

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• 2. Metabolic profiling of pulmonary vascular cells in chronic thromboembolic pulmonary hypertension

  To characterize the cell proliferative process that underlies the development of pulmonary hypertension in patients with thromboembolic pulmonary d...

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• 3. Assessing prehabilitation as preventive intervention to reduce postoperative complications

  The group is currently involved in a randomized control trial evaluating the impact of a prehabilitation program in the setting of cardiac surgery....

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• 4. Evaluating modalities of perioperative ventilatory support

  We are working on several physiological proof-of-concept studies and have promoted three international, multicentre, randomized controlled trials.

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• 5. Implementation of integrated care services with a digital health and systems medicine approach

  We are currently undertaking research projects addressed to clinical risk assessment and service selection, promotion of healthy lifestyles, collab...

  Investigació – Línies d'investigació