Resultats de la cerca

• Breast cancer

  Directed by Dr. Aleix Prat To evaluate the impact of the identification of the intrinsic molecular subtypes of breast cancer in the clinical set...

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• Cancer immunotherapy

  Directed Dr. Aleix Prat To establish an adoptive T-cell therapy program using Tumor-Infiltrating Lymphocytes (TIL) across cancer types. To iden...

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• Lung cancer

  Directed by Dr. Noemí Reguart Validate novel molecular technologies to streamline the screening of targetable biomarkers in non-small cell lung...

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• Upper gastrointestinal tumors

  Directed by Dr. Tamara Saurí To identify novel biomarkers predictive of survival and/or treatment response in pancreatic cancer, cholangiocarcin...

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• Urologic cancer

  Directed by Dr. Begoña Mellado and Dr. Oscar Reig To study the molecular mechanisms of resistance to taxanes and novel hormone-therapies in prec...

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• Dermoscopy, digital dermoscopy, confocal microscopy and new photonic and physic technologies

  Description of new algorithms, study of the evolution of lesions, new classifications and the use of telemedicine. Correlation of dermoscopy and mo...

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• Genetic epidemiology in melanoma and non-melanoma skin cancer

  Study of melanoma susceptibility genes in familial and sporadic melanoma. Identification of new genes and mechanisms of melanoma susceptibility usi...

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• Giant congenital nevi

  Global research approach including clinical, genetics and psychological aspects of giant congenital nevi.

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• Identification of genetic prognostic profiles in melanoma

  Evaluation of germline genetic factors implicated in the modulation of melanoma outcome. Evaluation of tumor mutational signatures obtained from ne...

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• Evaluation of immune response in melanoma

  Identification of polymorphisms in genes implicated in immunotolerance and immune-response that influence melanoma prognosis. Evaluation of blood i...

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• Analysis of the influence of the microbiota in skin cancer

   Evaluation of the role of the gut microbiome in the modulation of immunotherapy response and melanoma outcome.

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• Identification of biomarkers for melanoma

  Study of circulating free DNA (cfDNA) as a biomarker for melanoma surveillance. Study of circulating melanoma cells (CMC) and single cell sequencing.

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• Development of new treatment strategies for melanoma and other skin tumors

  Research in the dermatological implications of targeted therapies in melanoma. Immunotherapy in melanoma and non-melanoma skin cancer. Development...

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• Study of the mechanisms involved in carcinogenesis and photocarcinogenesis in melanoma and non-melanoma skin cancer

  Analysis of topical and oral photoprotection. Study of UV effect in skin and melanocytic nevi using imaging techniques and high-throughput molecula...

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• Functional validation of paternally-derived embryo proteins during early embryogenesis

  The goal of this line emerges from the recent results derived from the integrative analysis of the proteome and transcriptome from human sperm, ooc...

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• Characterization of exosomes isolated from seminal fluid and development of clinically relevant diagnostic and prognostic biomarkers

  Exosomes contained in the seminal fluid may contribute proteins and RNAs to the sperm. Our first goal is to characterize the protein and RNA conten...

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• Characterization of epigenetic signatures in the sperm chromatin

  We have identified a non-random distribution of proteins and genes along the sperm chromatin domains which may represent epigenetic marks involved...

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• Molecular alterations in semen from couples with idiopathic infertility

  Molecular alterations at the transcriptiomic and proteomic level are analyzed in sperm and seminal plasma from couples with idiopathic infertility...

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• Genetics of endocrine disorders

  We are  studying the genetic aspects of hereditary endocrine disorders (multiple endocrine neoplasia, congenital adrenal hyperplasia and monogenic...

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• Characterization of genes involved in the familial non-syndromic differentiated thyroid carcinoma

  Differentiated familial thyroid carcinoma represents 3-9% of thyroid carcinomas. Today, the genes involved in some rare syndromic forms in which th...

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