Resultats de la cerca

• Healthy aging - Alzheimer's disease continuum

  The study of Alzheimer's disease (AD) in preclinical and prodromal phases is needed for the design of new disease modifying therapeutic strategies....

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• Rare neurodegenerative dementias: Frontotemporal lobar degeneration and prion diseases

  I) Frontotemporal lobar degeneration our group has participated in several projects and publications in this field and collaborates with other grou...

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• Neuropathology of neurodegenerative diseases

  Our group works in close collaboration with the Neurological Tissue Bank (NTB) from the Hospital Clínic-IDIBAPS. The NTB of the Hospital Clínic-IDI...

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• Redox stress in aortic aneurysm formation and progression in Marfan syndrome

  Our aim is to find out which moieties and signaling pathways are impaired in redox physiology and stress in aortic vascular cells. We are also assa...

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• New pharmacological approaches to interfere in the Marfan syndrome-associated TGF-β hypersignaling

  We use TGF-β receptor peptide sequences to sequester soluble active TGF-β in excess to prevent the aortic aneurysm.

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• Non invasive characterization of arrhythmia substrate

  We aim to characterize the myocardial and electrical substrate in patients with atrial fibrillation and ventricular tachycardia in order to improve...

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• Characterization of cardiac mechanics in heart failure

  We aim to quantify and precisely describe underlying abnormalities in cardiac mechanics that could be corrected to improve the outcomes of patients...

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• Prediction of atrial fibrillation in patients at risk (Predict AF study)

  We aim to establish non invasive risk biomarkers based on imaging and blood tests to identify subjects that will develop atrial fibrillation in ord...

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• Identification of patients at risk of sudden death and heart failure after myocardial infarction

  We aim to characterize myocardial scar and cardiac remodelling to improve our identification of patients who will develop malignat ventricular arrh...

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• Identification of athletes at risk of sudden death

  We aim to characterize cardiac remodelling in response to exercise training and to identify those atletes at risk of presenting sudden death. Also,...

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• Characterization of hypertrophic hearts (INDEPTH-HCM)

  We aim to perform a in-depth myocardial characterization of hypertrophic cardiomyopathy: comprehensive multimodality imaging, tissue characterizati...

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• Identification of candidates for and impact of percutaneous therapies for heart valve disease

  We aim to understand the changes in valvular geometry and cardiac performance before and after implantation of novel percutanoeusly implanted devic...

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• Usefulness of non-invasive cardíac imaging in the identification of acute coronary syndromes

  We explore the additive diagnostic value of several non-invasive cardiac imaging modalities for the identification of acute coronary syndrome among...

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• To investigate the role of mitochondrial DNA in synapse elimination and neurodegeneration in genetic models of neurodegenerative diseases

  The loss of neuronal synapses is a phenomenon that occurs in the early stages of neurodegenerative disorders. We hypothesize that synaptic neurodeg...

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• To study the mechanisms that alter amyloid beta (Aβ) clearance and disposal of dysfunctional mitochondria

  Ab accumulation is a primary step of Alzheimer’s disease (AD). Noteworthy, while in early-onset familial AD increased Ab burden mainly results from...

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• Study the role of mitochondrial function in neuroinflammation and amyloid beta (Aβ)-induced cell death

  Neuroinflammation is a key pathological feature of Alzheimer’s disease (AD) that results primarily from the presence of chronically activated micro...

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• Psychotic and affective disorders in children and adolescents

  The research line has been active for the last fourteen years. Both diseases are considered neurobiological disorders with an important genetic com...

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• Anorexia and other eating disorders

  Our group has studied clinical, neuropsychological and brain alterations in adolescents diagnosed with these disorders over the last fifteen years....

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• Obsessive-compulsive disorder (OCD) and Tourette syndrome

  We study patients’ neuroimaging and genetic characteristics in order to differentiate endophenotypes and also use machine learning methodology to p...

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• Autism spectrum disorders (ASD)

  Our group has published studies on cognitive and neuroimaging abnormalities in ASD children and adolescents and their siblings as well as ongenetic...

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