Resultats de la cerca

• Alcoholism and other addictions, and related comorbidities: new diagnosis tools and treatment

  Examples: 1) Identification of the pattern of cannabis, tobacco, and alcohol use as a function of gender and psychiatric comorbidities that predic...

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• Therapeutic use of uric acid as peroxynitrite scavenger in acute ischemic stroke

  Studies at our lab have identified the value of uric acid administration after a brain embolism and how it acts in synergy with reperfusion therapi...

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• The chemical optimization of cerebral embolectomy

  Mechanical thrombectomy (MT) increases brain reperfusion and the likelihood of good outcome in patients with acute stroke but only about one third...

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• Blood-brain barrier disruption in cerebrovascular diseases

  Blood-brain barrier (BBB) disruption is one of the major deleterious mechanisms implicated in the physiopathology of Central Nervous System disease...

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• Brain-gut cross-talk in stroke: targeting gut barrier dysfunction and immune responses to improve stroke outcome

  Infection is a frequent complication of stroke associated with mortality and poor neurological recovery. Recent experimental studies show that post...

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• Vascular changes with aging and in animal models of vascular dementia

  Vascular dementia (VaD) is recognized as one of the leading causes of cognitive impairment and dementia in the elderly, and has become one of the m...

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• Inflammatory and immune responses to stroke

  Brain cell death after acute stroke triggers inflammation, involving glial and endothelial cell activation, invasion of leukocytes to the damaged t...

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• Sphingolipid and mitochondrial oxidative-stress regulation of cell death

  The sphingolipid rehostat greases the machinery of cell death unleashing the molecular players involved in the execution of cell death in its diver...

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• Mechanisms responsible for cholesterol transport to the mitochondria and role in NASH, hepatocellular carcinoma and Alzheimer’s disease

  As cholesterol is a major determinant of the structural properties of membrane bilayers, we aimed to understand the mechanisms underlying the intra...

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• Translational research in nonalcoholic steatohepatitis (NASH): development of NASH in a humanized mouse model to identify potential targets in human NASH

  As the biology of mice and humans differ, we have developed and established a model of mice with humanized liver, which may increase the translatio...

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• Contribution of sphingolipids and cholesterol in acute liver failure

  Disect the role of the mutual regulation between sphingolipids and cholesterol in lysosomes and mitochondrial turnover in the regulation of drug in...

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• Mitochondrial cholesterol and glycosphingolipids in liver fibrosis. Reciprocal regulation between HIF1a and StARD1 in steatohepatitis and hepatocellular carcinoma

  We aimed to study the impact of mitochondrial cholesterol and glycosphingolipids in the stabilization/activation of HIF1a and its impact  in the pr...

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• ER stress-mitochondrial cholesterol axis in obesity-associated insulin resistance and comorbidities

  Our purpose is to understand the impact of mitochondrial cholesterol in adipose tissue and muscle and their interplay in insulin resistance and non...

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• Lysosomal proteases role during tissue remodeling and regeneration in liver and kidney injury

  This research line focuses on identifying new therapeutic targets for liver and kidney disease treatment by studying the cellular and molecular pat...

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• Development of physiomimetic experimental models

  The use of physiomimetic experimental models is transforming respiratory research by providing biomimetic environments that closely replicate lung...

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• Optimization of stem cell therapy for acute lung injury

  Development of a stem cell training program based on individual effects of different biomechanical environmental paràmetres to produce highly thera...

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• Mechanisms of cardiac arrhythmias in high-level athletes

  Heavily trained athletes have been found to be at a higher risk of atrial fibrillation and right ventricular arrhythmias than their sedentary count...

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• Extra-cardiac consequences of very high-intensity physical activity

  The deleterious consequences of high-intensity physical activity may not be limited to the heart. We are currently interested in testing whether he...

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• Characterization of the pathophysiology of cardiac arrhythmias

  We are also interested in uncovering the mechanisms of the deleterious atrial arrhythmogenic cardiac remodelling occurring in the absence of overt...

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• Understanding the biogenesis and consumption of lipid droplets: decoding the metabolic syndrome?

  Directed by Albert Pol  Accumulation of lipid droplets is the cellular hallmark of a plethora of prevalent diseases. Understanding the life-cycle...

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