Resultats de la cerca

• Impact of exercise programs in the treatment PBC-associated fatigue

  Up to 50% of patients with PBC experience clinically significant fatigue and, it is more common in younger patients. Fatigue diminishes quality of...

  Investigació – Línies d'investigació

• Clinical and biological characterization of patients with Wilson’s disease

  Wilson's Disease is a rare genetic condition characterized by copper deposition mainly in the liver and other tissues afterwards. Clinical presenta...

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• Epidemiology of drug-induced liver disease

  The real incidence of drug-induced liver injury is difficult, but it seems clear that it is increasing due to the growth of prescriptions. Epidemio...

  Investigació – Línies d'investigació

• CAR-T cells for the treatment of solid tumours

  After the success of CAR-T cells in hematologic malignancies, the translation of CAR-T cells to solid tumours is the next big challenge in the fiel...

  Investigació – Línies d'investigació

• CAR-T cells for the treatment of hematologic malignancies

  Resistance to CD19-CAR-T cells in hematologic malignancies can appear linked to loss or downregulation of CD19 expression or an immunosuppressive t...

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• Understanding the limitations of CAR-T cells in preclinical studies

  The progress of CAR-T cells is limited by a poor understanding of how the design and signaling of these CAR proteins affect T cell efficacy and per...

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• Other cancer immunotherapies and combination treatments

  While T-cell based immunotherapies have revolutionized cancer treatment, a majority of patients fail to respond or relapse after a certain period o...

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• Development, evaluation and implementation of digital technologies in the field of mental health

  New digital technologies have opened a wide range of opportunities and challenges in the mental health field. During the last decade, our team have...

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• Critical conditions for disease onset or prognosis

  To evaluate clinical and molecular features that may condition disease onset, severity, evolution and co-morbidities. Description of the natural hi...

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• Identification of genes responsible for genetic disorders

  The strategic objective of this research line is to investigate the genetic, anatomopathological and biochemical bases, as well as the physiopathol...

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• Physiopathology of disease

  To search for the physiopatological bases of these diseases we use a combination of the classical and advanced omics technologies (metabolomics, pr...

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• Validation of models, mechanisms, and biomarkers of disease

  To confirm the pathogenicity of a certain gene or molecular mechanism, we validate cell models derived from patient to study the disease. We use fi...

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• Therapeutic approaches

  This line involves the testing of chemical and peptide libraries, as well as genetic edition strategies. Selection has been made on disease-causing...

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• Ras GTPases: regulation and new roles in tumorigenesis

  Ras proteins are GTPases that regulate signal transduction pathways, which control cell proliferation, differentiation, survival and apoptosis. K-R...

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• Intracellular cholesterol transport and membrane repair in lysosomal diseases

  The endolysosomal (LE/Lys) compartment is the main intracellular reservoir of cholesterol and acts as a sorting center from which cholesterol is de...

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• Cell Death, Senescence, and Cancer Precision Medicine

  Led by Dr. J. Montero.  The Montero Lab studies cell death, senescence and cancer precision medicine at the University of Barcelona's Department o...

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• Replication Stress and Autophagy in Chromosome Instability

  Led by C. Mauvezin. Genomic instability is a hallmark of tumor cells, resulting from errors in mitotic progression such as prolonged mitosis, DNA...

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• Translational research in liver cancer

  Our scientific contributions to advancing knowledge in liver cancer during the last 15 years are summarized as follows: we contributed to the class...

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• Molecular and immune classification of HCC

  The group contributed to the molecular classification of HCC (Hoshida, NEJM 2008, Chiang Cancer Research 2008) and to the generation of gene signat...

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• Identification of determinants of response to immunotherapy in HCC

  We developed an 11-gene signature able to predict response to immune checkpoint inhibitors in HCC (Haber Gastroenterology 2022). We also contribute...

  Investigació – Línies d'investigació