Resultats de la cerca

• Physiology and pathophysiology of pain and chronic itch. Study of the ion channels involved in neuronal excitability in the sensory nervous system

  Study of the ionic channels that regulate the electrical activity of sensory neurons and how they are altered during the pathology. Identification...

  Investigació – Línies d'investigació

• Microglia-neuron crosstalk in health and disease

  To understand how neuron-glia communication contributes to synapse and neuronal loss, and modulates neuronal activity in neurodegeneration. A majo...

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• N-glycosilation channelopathies and synaptic function

  Investigation how the activity of synaptic proteins and the synaptic function is affected by physiological and pathological N-glycosylation and its...

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• Utility of ECG imaging in locating abnormal conduction zones and in mapping arrhythmias.

  This involves obtaining images of the heart’s electrical activity in a noninvasive manner in order to apply this knowledge to developing ablation s...

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• Role of stimulation of the conduction system in cardiac stimulation.

  Study of new physiologic stimulation techniques. Assessment of results and complications. 

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• Study of the utility of new mapping tools in ablation of ventricular tachycardia

  Treatment of ventricular tachycardia requires detailed mapping of the circuits. Currently, catheters are used that are more accurate than is requir...

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• Biomarkers, transplant immunology and cell therapy in renal and pancreatic transplantation.

  Directed by Dr. Fritz Diekmann and Dr. Pedro Ventura In the last years we have worked with exosomes, Chimeric antigen receptor-T cells (CAR-Ts), M...

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• New technologies and biomarkers in dialysis

  Directed by Dr. Francesc Maduell During the last years we analyzed and improved the quality of dialysis, especially studying vascular calcificatio...

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• Pathophisiology and innovative therapies in acute and chronic kidney disease

  Directed by Dr. Luis F Quintana and Dr Miquel Blasco. We were studying endothelial dysfunction and complement disorders in the context of chronic...

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• Artificial intelligence

  Directed by Dr. Ignacio Revuelta We are developing predictive AI models that classify patients in terms of their immunological risk and, consequen...

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• Novel biomarkers and clinical relevance of the persistence of cccDNA in chronic HBV infection

  There is no curative treatment for HBV infection. This is mainly due to the persistence of cccDNA (covalently closed circular DNA) in the nucleus o...

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• Natural history of chronic HBV infection in different clinical situations

  There are very few data on the role of the immune response (and especially of the specific or adaptive) in the viral events that characterize the n...

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• Clinical, virological and immunological predictors of response after antiviral treatment interruption in chronic hepatitis B

  Despite the existence of an efficient hepatitis B vaccine for more than 30 years, hepatitis B virus (HBV) infection is still a global health proble...

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• Characterization of humoral and intrahepatic HBV immune responses and the effect of antiviral therapy

  Although most studies have focused on the analysis of T cell responses in chronic hepatitis B, humoral / B cell responses are important for prevent...

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• Strategies of hepatitis C microelimination in our geographical area, focused in PWID and psychiatric populations

  Significant scale-up of treatment among people who inject drugs (PWID) is crucial to achieve WHO hepatitis C virus (HCV) elimination targets. We ha...

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• Long-term impact of Hepatitis C cure in patients with advanced liver disease

  Portal hypertension (PH) is the key driver of hepatic decompensation in patients with advanced chronic liver disease. Accordingly, interventions th...

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• Understanding the immunopathogenesis of autoimmune hepatitis (AIH) to develop risk stratification tools at presentation

  The incidence of AIH has been steadily increasing within the last decades.  However, standard treatment of the disease, which consists of corticost...

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• Evolution of AIH in special populations (pregnancy, compensated and decompensated cirrhosis)

  Approximately 30% of patients with AIH have cirrhosis at the time of diagnosis, and 20-30% of the remaining patients will develop cirrhosis during...

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• Identification of biomarkers of success of immunosuppression withdrawal and treatment response in AIH

  We have performed a prospective clinical trial to identify biomarkers able to predict the success of immunosuppression withdrawal in patients with...

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• Natural history of modern primary biliary cholangitis (PBC) and predictive factors of portal hypertension in patients in non-cirrhotic patients with PBC

  PBC is chronic liver disease affecting small bile ducts. If left untreated, patients will develop ductopenia and cirrhosis with all its complicatio...

  Investigació – Línies d'investigació