Resultats de la cerca

• Clinical applicability of genomic copy-number alterations and aneuploidy

  Chromosomal aneuploidy results in the acquisition of copy-number alterations, which occur early in tumorigenesis and are positively selected throug...

  Investigació – Línies d'investigació

• Intratumor heterogeneity as a novel biomarker in colorectal cancer

  Elucidating the role of genomic instability, which represents the molecular engine that fuels intratumor heterogeneity in carcinomas, is critical f...

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• Functional consequences of whole-genome doubling and its impact on disease outcome

  There is growing evidence that whole-genome doubling occurs early in tumorigenesis and triggers genetically unstable near-tetraploid cells. In addi...

  Investigació – Línies d'investigació

• 1-Which is the role of translational control of gene expression in liver disease and cancer?

  To understand the molecular mechanisms involved in the development and progression of liver disease and cancer, with a focus on the aberrant reprog...

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• 2-What is the significance and underlying mechanisms linking obesity with liver disease and cancer?

  To decipher mechanisms underpinning the detrimental impact of obesity in liver disease and cancer. This knowledge is crucial for advancements in tr...

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• 3-How does deregulation of pathways that control angiogenesis contribute to progression of liver disease and cancer?

  To define the molecular and cellular mechanisms that regulate/dysregulate angiogenesis in liver disease and cancer and define their functional rele...

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• 2-Multiple sclerosis and other demyelinating syndromes

  This work is leading to a comprehensive understanding of the etiology and pathophysiology of demyelinating disorders including multiple sclerosis,...

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• 3-Pediatric neuroimmunologic diseases

  This research is focused on identifying new antigens associated with pediatric autoimmune encephalitis and demyelinating diseases, characterizing t...

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• Advanced Therapies

  Coordination of the transfer of basic research in advanced therapies from the Hospital Clínic to its clinical application, through the scientific e...

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• Pharmacovigilance

  Research on the molecular and pathophysiological mechanisms of adverse drug reactions and implementation of active pharmacovigilance systems that a...

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• Support to clinical research: Design, methodology, regulatory, project management, monitoring, data management and statistics

  Optimization of methodological and statistical support for clinical research and full-service CRO for phase I-IV clinical trials sponsored by acade...

  Investigació – Línies d'investigació

• Ethics in clinical research

  Search for quality and the extent and context of application of current ethical principles in clinical research projects. It is developed in group...

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• Pharmacogenetics and pharmacogenomics

  Development of studies to relate genetics with the activity and response to the action of drugs.

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• Coordination of multinational projects and research networks

  Active collaboration in national clinical research networks, such as SCReN (Spanish clinical Research Network), to carry out multicenter clinical r...

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• Etiopathogenesis in endometriosis and adenomyosis

  Directed by: Maria Angels Martínez Zamora To evaluate new insights in the knowledge of the origin and recurrence of endometriosis and adenomyosis...

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• Human papillomavirus (HPV) infection and prevention

  Directed by: Marta del Pino To understand the natural history of HPV infection will allow us to improve both prevention strategies and related les...

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• Interplay between HBV, HDV and host factors: impact on liver disease progression

  Hepatitis delta is caused by infection with the hepatitis D virus (HDV) and is considered to be the most severe form of human viral hepatitis. Chro...

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• Glutamatergic signalling: functional interaction between AMPARs, auxiliary subunits and novel interacting proteins

  Physiological characterization of AMPAR and interacting proteins (TARPs and CPT1C) in neurons and glial cells and the role in memory and sensibilit...

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• Pathophysiology of the NMDAR receptor and personalised medicine for GRIN-related disorders.

  Functional studies of NMDAR receptors with new block synthesis compounds and positive allosteric modulators in the framework of neurological diseases.

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• Ocular physiology: dry eye physiopathology and sensory neurons on the ocular surface. Pathophysiology of the drainage of aqueous humour and the physiopathology of glaucoma

  Study of the ionic channels involved in the detection of painful and irritating stimuli on the ocular surface and its role in eye pathologies such...

  Investigació – Línies d'investigació