Resultats de la cerca

• Impact of lifestyle on diabetes

  Diabetes is a serious global health problem due to its prevalence (more than 425 million people), the economic burden and the number of deaths it c...

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• Circulating microRNAs as potential biomarkers and therapeutic targets in type 2 diabetes

  We are interested in finding circulating microRNAs as biomarkers for prediabetes and diabetes, for its micro- and macrovascular complications and f...

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• New therapeutic targets for the treatment of type 2 diabetes and obesity

  The molecular mechanisms underlying the onset and progression of type 2 diabetes is crucial to find novel targets and therapeutic strategies to tre...

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• Mechanisms and treatment of endothelial dysfunction in type 2 diabetes

  Diabetes has a detrimental impact on endothelial cell function. In this context, we investigate the impact of glucose oscillations on cardiovascula...

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• Bacteremia

  We have been prospectively collecting data on all episodes of bacteremia in the hospital since 1990. This makes it possible to analyze the epidemio...

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• Immunocompromised patients

  Register of patients with blood cancer undergoing chemotherapy or bone-marrow transplant. The main areas of study are infections by multiresistant...

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• Bone and joint infections

  European Register of Infections/AIDS on joint prostheses, aimed at studying diagnostic methods and the efficacy of new antibiotics in this type of...

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• Intestinal microbiota

  We are developing a system to make it possible to perform fecal transplants from healthy volunteers to patients with Clostridium difficile and whic...

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• Characterization of the functional impact of driver mutations and the analysis of new potential therapeutic approaches

  Genetic studies have led to the identification of novel recurrent somatic mutations with predicted functional impact, offering new potential therap...

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• Development of predictive models recapitulating tumor heterogeneity and their impact on disease evolution, therapy resistance and susceptibility to novel targeted therapies

  Due to the high heterogeneity and complexity of B lymphoid malignancies, the analysis of the effect of novel targeted drugs in different mutational...

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• Mechanisms of resistance to targeted therapy

  Treatment with novel targeted drugs like the Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib or the Bcl-2 antagonist venetoclax improved outcome...

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• Analyze different biomarkers to predict patients’ outcomes and prognosis

  Patients with different complications of cirrhosis will be prospectively studied. Urine and blood samples will be analyzed to assess the accuracy o...

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• Characterization of systemic and hepatic inflammation and gut microbiome in patients with cirrhosis, encompassing all stages of the disease

  Patients will be divided according to disease stage: from compensated to decompensated and ACLF. Systemic and hepatic inflammation will be investig...

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• Screening for liver fibrosis. A population-based study in European countries. The 'LiverScreen' project

  The aim of this project is to prove the cost-effectiveness of screening for liver fibrosis in general population using transient elastography.

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• Studying different strategies to halt disease progression

  A multicenter, double-blind, placebo controlled randomized clinical trial to study the safety and efficacy of the combination of simvastatin plus r...

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• Sleep and sleep disorders

  A clinical and electrophysiological assessment of normal sleep in humans and of sleep disorders including the anti-IgLON5 disease, REM sleep behavi...

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• Epilepsy

  Characterization of the epileptogenic activity and the surgical and medical therapy of the refractory epilepsy using functional MRI, video-EEG and...

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• Neuropathic pain

  Electrophysiological evaluation of the neuropathic pain using nocioceptive evoked potentials and other tools including the startle reaction.

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• Motor control

  Assesment of the motor control in healthy subjects and in patients with neurological diseases using acoustic and somatosensorial stimul and prepulse.

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• Precision screening, diagnosis, and staging for enhanced liver cancer outcomes

  Directed by Maria Reig  Effective stratification of patients according to their cancer risk is essential to ensure cost-effective screening progra...

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