Resultats de la cerca

• Mechanisms of cardiac arrhythmias in high-level athletes

  Heavily trained athletes have been found to be at a higher risk of atrial fibrillation and right ventricular arrhythmias than their sedentary count...

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• Extra-cardiac consequences of very high-intensity physical activity

  The deleterious consequences of high-intensity physical activity may not be limited to the heart. We are currently interested in testing whether he...

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• Characterization of the pathophysiology of cardiac arrhythmias

  We are also interested in uncovering the mechanisms of the deleterious atrial arrhythmogenic cardiac remodelling occurring in the absence of overt...

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• Understanding the biogenesis and consumption of lipid droplets: decoding the metabolic syndrome?

  Directed by Albert Pol  Accumulation of lipid droplets is the cellular hallmark of a plethora of prevalent diseases. Understanding the life-cycle...

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• Lipid droplets as innate immunity hubs

  Directed by Albert Pol  We recently described a new antimicrobial function of cytosolic lipid droplets in the cellular defence against intracellul...

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• Lipid droplets role in inflammation

  Directed by Marta Bosch  Lipid droplets are accumulated in multiple inflammatory processes. With especial attention to the pro-inflammatory transc...

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• Lipid droplets, a new cancer hallmark

  Directed by Albert Pol  Lipid droplets are a hallmark of multiple cancers, our research focuses in understanding their role in liquid tumours to d...

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• Lineage-specification of pMHC-NP-induced antigen-specific T-regulatory type 1 (TR1) cells

  This project seeks to define the mechanisms underlying the lineage origin and specification of the autoreactive TR1 cells arising in response to pM...

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• Phenotypic, transcriptional and epigenetic make up of pMHC-NP-induced human autoantigen-specific TR1 cells in humanized mouse models

  We seek to define the phenotypic, transcriptional and epigenetic make-up of human autoantigen-specific TR1 cells arising in humanized mice in respo...

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• Advancing antigen-specific nanomedicines for the treatment of organ-specific and systemic autoimmune diseases

  This project involves the development of novel methodologies to identify candidate pMHC-based nanomedicines for a variety of chronic inflammatory d...

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• Role of autophagy in autoantigen presentation during T-cell ontogeny and autoimmunity

  This line of research focuses on studying the role of autophagy in the presentation of type 1 diabetes-relevant autoantigens by thymic and peripher...

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• Engineering of recombinant peptide-major histocompatibility complexes suitable for eliciting autoreactive T-regulatory type 1 cells in vivo

  This projects seeks to engineer novel recombinant pMHC structures suitable for human therapeutic application.

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• Understanding pancreatic carcinogenesis

  Directed by Dr. Cristina Fillat  Pancreatic carcinogenesis is well defined as a multistage process accompanied by distinct morphological and histo...

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• Oncolytic virotherapies against pancreatic cancer

  Directed by Dr. Cristina Fillat  Oncolytic adenoviruses replicate in the tumors leading to oncolysis and triggering an immune cell infiltration in...

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• Preclinical gene therapy /genome editing studies for metabolic rare diseases

  Directed by Dr. Cristina Fillat  Glutaric aciduria type I (GA-I) is a metabolic inherited disease due to mutations in the GCDH gene. Individuals w...

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• Utility of cardiac magnetic resonance in the diagnosis and treatment of arrhythmias

  Obtaining MRI and analysis of the arrhythmia substrate using specialized software. 

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• Role of sinusoidal cells in the progression and regression of liver diseases

  We aim at comprehensively characterizing the molecular mechanisms responsible for sinusoidal cells de-regulation during the progression of liver pa...

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• Sinusoidal communications in liver diseases

  Using original bioengineered in vitro models, we aim at describing the effects that modifications in sinusoidal biomechanics, occurring during live...

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• Aging & liver diseases

  Considering the increase in worldwide population median age and life expectancy, we devote a significant part of our resources at characterizing, i...

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• Molecular pathology of B-cell neoplasms

  Directed by Elías Campo To characterize the molecular alterations involved in the development and progression of lymphoid neoplasms, particularly...

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